Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis

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dc.contributor.authorBorzone, G
dc.contributor.authorMoreno, R
dc.contributor.authorUrrea, R
dc.contributor.authorMeneses, M
dc.contributor.authorOyarzun, M
dc.contributor.authorLisboa, C
dc.date.accessioned2024-01-10T13:11:29Z
dc.date.available2024-01-10T13:11:29Z
dc.date.issued2001
dc.description.abstractAdministration of bleomycin into the lungs of experimental animals has been utilized as a model to understand human pulmonary fibrosis. Most of the studies, however, have focused on early stages of the lung reaction. We hypothesized that chronic stages of the model may not mimic idiopathic pulmonary fibrosis, since in preliminary studies, lung volume and compliance were not decreased. Eight male Sprague-Dawley rats receiving intratracheal bleomycin (0.5 U/100 g body weight) underwent measurement of FRC, inspiratory capacity, and lung compliance 120 d later. Lung histologic changes were evaluated using light microscopy. Eight rats without intervention served as controls. Results show that our model, in early stages, has histologic changes no different from those previously described elsewhere. In chronic stages, however, the model does not behave as a restrictive syndrome: FRC is normal or increased, whereas lung compliance is normal. Focal peribronchiolar inflammation and fibrosis associated with paracicatricial emphysematous changes are the main histologic features of long-term lung remodeling after bleomycin. We conclude that while the chronic stages of the model may be informative in understanding mechanisms of fibrosis, care should be taken not to extrapolate to human idiopathic pulmonary fibrosis. We speculate that the model might resemble a particular subgroup of human interstitial lung disease, namely, those involving peribronchiolar structures.
dc.fechaingreso.objetodigital2024-05-20
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1164/ajrccm.163.7.2006132
dc.identifier.eissn1535-4970
dc.identifier.issn1073-449X
dc.identifier.pubmedidMEDLINE:11401889
dc.identifier.urihttps://doi.org/10.1164/ajrccm.163.7.2006132
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78052
dc.identifier.wosidWOS:000169337400029
dc.information.autorucMedicina;Borzone G;S/I;99892
dc.information.autorucMedicina;Lisboa C;S/I;98551
dc.issue.numero7
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1653
dc.pagina.inicio1648
dc.publisherAMER THORACIC SOC
dc.revistaAMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
dc.rightsacceso restringido
dc.subjectENDOTRACHEAL BLEOMYCIN
dc.subjectSURFACTANT
dc.subjectHAMSTERS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis
dc.typeartículo
dc.volumen163
sipa.codpersvinculados99892
sipa.codpersvinculados98551
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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