Maternal factors modulate the increase in vasoactive substances during rat pregnancy

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dc.contributor.authorGiacaman, A
dc.contributor.authorSalas, SP
dc.contributor.authorRosso, P
dc.date.accessioned2024-01-10T13:50:20Z
dc.date.available2024-01-10T13:50:20Z
dc.date.issued1999
dc.description.abstractObjective: To explore if the changes in vasoactive substances observed during early pregnancy in the rat are modulated by maternal or fetoplacental factors.
dc.description.abstractMethods: Urinary excretion of cGMP, 6-keto-prostagladin-F1 alpha (6-keto-PGF1 alpha), thromboxane B-2 and kallikrein activity was measured in pregnant (P, n = 11), pseudopregnant (PSP, n = 12), and virgin (n = 13) rats and in ovariectomized virgin rats supplemented with slow-release pellets containing either progesterone (50 mg/pellet) or estradiol (0.5 mg/pellet) or a combination of both hormones, for 21 days.
dc.description.abstractResults: The cGMP excretion was higher in PSP rats than in virgin rats at day 5 (virgin = 82 +/- 7, P = 93 +/- 5, PSP = 110 +/- 8 nmol/24 h, p < 0.05); at day 10, values were significantly increased in P and PSP rats. 6-keto-PGF1 alpha excretion was similarly elevated in P and PSP rats at day 5 (virgin = 120 +/- LO, P = 160 +/- 10, and PSP = 174 +/- 14 ng/24 h, p < 0.01). This trend was still present at day 10. Thromboxane B-2 excretion showed a nonsignificant increase in P and PSP rats in day 5; at: day 10, values were significantly elevated in both experimental groups (virgin = 23 +/- 2, P = 32 +/- 4, and PSP = 32 +/- 2 ng/24 h, p < 0.05). Kallikrein excretion was significantly increased in PSP and P rats at days 5 and 10. Estradiol or progesterone administration caused a significant decrease in serum aldosterone and an increase in urinary kallikrein activity.
dc.description.abstractConclusions: These results indicate that during the first half of rat pregnancy, the increment in vasoactive substances is modulated by maternal and not by fetoplacental factors.
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3109/10641959909009608
dc.identifier.issn1064-1955
dc.identifier.pubmedidMEDLINE:10463997
dc.identifier.urihttps://doi.org/10.3109/10641959909009608
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79523
dc.identifier.wosidWOS:000079425300003
dc.information.autorucMedicina;Salas SP;S/I;51518
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final34
dc.pagina.inicio23
dc.publisherMARCEL DEKKER INC
dc.revistaHYPERTENSION IN PREGNANCY
dc.rightsacceso restringido
dc.subjectpseudopregnancy
dc.subjectovarian steroids
dc.subjectprostaglandins
dc.subjecturinary kallikrein activity
dc.subjectcGMP
dc.subjectrats
dc.subjectNITRIC-OXIDE SYNTHESIS
dc.subjectATRIAL NATRIURETIC FACTOR
dc.subjectPLASMA-VOLUME EXPANSION
dc.subjectURINARY-EXCRETION
dc.subjectBLOOD-PRESSURE
dc.subjectCARDIAC-OUTPUT
dc.subjectRENAL-FUNCTION
dc.subjectFETAL GROWTH
dc.subjectALDOSTERONE
dc.subjectPROGESTERONE
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleMaternal factors modulate the increase in vasoactive substances during rat pregnancy
dc.typeartículo
dc.volumen18
sipa.codpersvinculados51518
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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