Prevalence of the angiotensin I converting enzyme insertion deletion polymorphism, plasma angiotensin converting enzyme activity, and left ventricular mass in a normotensive Chilean population

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dc.contributor.authorJalil, JE
dc.contributor.authorPiddo, AM
dc.contributor.authorCordova, S
dc.contributor.authorChamorro, G
dc.contributor.authorBraun, S
dc.contributor.authorJalil, R
dc.contributor.authorVega, J
dc.contributor.authorJadue'P, L
dc.contributor.authorLavandero, S
dc.contributor.authorLastra, P
dc.date.accessioned2024-01-10T13:52:31Z
dc.date.available2024-01-10T13:52:31Z
dc.date.issued1999
dc.description.abstractThe aim of this study was to estimate the prevalence of the different alleles of the angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and associated plasma ACE activity, as well as cardiac echocardiographic structure, in a healthy Chilean population. We selected 117 healthy normotensive subjects (aged 45 to 60 years, middle socioeconomic status, nonobese, and nondiabetic) from a population-based study concerning the prevalence of risk factors for chronic diseases (Conjunto de Acciones Para la Reduccion Multifactorial de las Enfermedades no Transmisibles [CARMEN]),
dc.description.abstractThe frequencies of the I and D alleles were 0.57 and 0.43, respectively. Mean plasma ACE activity was 15.3 +/- 3.9 U/mL. Compared with subjects with the II genotype, plasma ACE activity was significantly higher in subjects with the ID and DD genotypes with no difference between them. No correlation was observed between blood pressure and plasma ACE activity. Among the three different genotypes there was no difference in left ventricular (LV) dimensions or in LV mass. No correlation between plasma ACE activity and LV mass was observed for either gender or different genotypes. Multivariate linear regression analysis using LV mass and LV mass index as dependent variables showed independent effects (P < .05) for gender (higher LV mass in men) and diastolic blood pressure, but not for the DD genotype.
dc.description.abstractIn conclusion, in this population, the presence of the D allele on the ACE gene determined higher circulating ACE activity. However, in this normotensive healthy population, male gender and diastolic blood pressure, but not the presence of the D allele, were associated with increased LV mass. American Journal of Hypertension, Ltd.
dc.fechaingreso.objetodigital2024-04-11
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0895-7061(99)00040-0
dc.identifier.issn0895-7061
dc.identifier.pubmedidMEDLINE:10411367
dc.identifier.urihttps://doi.org/10.1016/S0895-7061(99)00040-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79668
dc.identifier.wosidWOS:000080947200006
dc.information.autorucMedicina;Jalil J;S/I;99946
dc.issue.numero7
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final704
dc.pagina.inicio697
dc.publisherELSEVIER SCIENCE INC
dc.revistaAMERICAN JOURNAL OF HYPERTENSION
dc.rightsacceso restringido
dc.subjectangiotensin converting enzyme polymorphism
dc.subjectangiotensin II
dc.subjectMYOCARDIAL-INFARCTION
dc.subjectGENETIC-POLYMORPHISM
dc.subjectINCREASED RISK
dc.subjectASSOCIATION
dc.subjectLEVEL
dc.subjectALLELE
dc.subjectASSAY
dc.subjectSARCOIDOSIS
dc.subjectDILATION
dc.subjectLINKAGE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePrevalence of the angiotensin I converting enzyme insertion deletion polymorphism, plasma angiotensin converting enzyme activity, and left ventricular mass in a normotensive Chilean population
dc.typeartículo
dc.volumen12
sipa.codpersvinculados99946
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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