Urinary kallikrein excretion in the human menstrual cycle, normal pregnancy and lactation

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dc.contributor.authorValdes, G
dc.contributor.authorCorthorn, J
dc.contributor.authorOyarzun, E
dc.contributor.authorBerrios, C
dc.contributor.authorForadori, A
dc.contributor.authorGermain, AM
dc.contributor.authorVillarroel, L
dc.date.accessioned2024-01-10T14:22:22Z
dc.date.available2024-01-10T14:22:22Z
dc.date.issued1998
dc.description.abstractObjectives To evaluate the temporal pattern of active and total urinary kallikrein excretion during the menstrual cycle, pregnancy and lactation, and to associate changes in kallikrein excretion with those of ovarian and placental hormones.
dc.description.abstractStudy design Nine volunteer women with ovulatory menstrual cycles and ten women who underwent physiological gestations were followed prospectively. Urine was collected on days 10, 16, 21 and 26 of the cycle and every 14 days from 4 to 13 weeks, and in weeks 15-17, 21-25 and 33-36 of gestation. Urinary active and total kallikrein were determined using DL-VAL-LEU-ARC pNA, estrogens and pregnanediol glucuronides by enzyme immunoassay, and total human chorionic gonadotropin (hCG) by an immunoradiometric assay.
dc.description.abstractResults Urinary active and total kallikrein levels remained stable during the ovulatory menstrual cycle; both forms increased in the first 15 weeks of pregnancy, and decreased in lactation below the values observed during the menstrual cycle.
dc.description.abstractConclusions The rise of urinary kallikrein in early gestation suggests that the kallikrein-kinin system may participate in the vasodilatatory changes necessary for the uterine and systemic adaptations of physiological gestation. In early pregnancy, renal kallikrein production is possibly stimulated by a trophoblastic signal.
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.issn1359-8635
dc.identifier.wosidWOS:000078050400006
dc.information.autorucMedicina;Foradori A;S/I;47695
dc.information.autorucMedicina;Germain A;S/I;55575
dc.information.autorucMedicina;Oyarzún E;S/I;54261
dc.information.autorucMedicina;Valdés G;S/I;98654
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final481
dc.pagina.inicio474
dc.publisherPARTHENON PUBLISHING GROUP
dc.revistaPRENATAL AND NEONATAL MEDICINE
dc.rightsacceso restringido
dc.subjectkallikrein
dc.subjectgestation
dc.subjectmenstrual cycle
dc.subjectlactation
dc.subjecthuman chorionic gonadotropin
dc.subjectRAT
dc.subjectLOCALIZATION
dc.subjectHYPERTENSION
dc.subjectUTERUS
dc.subjectKIDNEY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleUrinary kallikrein excretion in the human menstrual cycle, normal pregnancy and lactation
dc.typeartículo
dc.volumen3
sipa.codpersvinculados47695
sipa.codpersvinculados55575
sipa.codpersvinculados54261
sipa.codpersvinculados98654
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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