Crosstalking interactions between P2X4 and 5-HT3A receptors

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dc.contributor.authorChang-Halabi, Yuan
dc.contributor.authorCordero, Jose
dc.contributor.authorSarabia, Xander
dc.contributor.authorVillalobos, Daniela
dc.contributor.authorBarrera, Nelson P.
dc.date.accessioned2025-01-20T20:10:20Z
dc.date.available2025-01-20T20:10:20Z
dc.date.issued2023
dc.description.abstractIonotropic receptors are ligand-gated ion channels triggering fast neurotransmitter responses. Among them, P2X and 5-HT3 receptors have been shown to physically interact each other and functionally inducing cross inhibitory responses. Nevertheless, despite the importance of P2X4 and 5-HT3A receptors that mediate for example neuropathic pain and psychosis respectively, complementary evidence has recently started to move forward in the understanding of this interaction. In this review, we discuss current evidence supporting the mechanism of crosstalking between both receptors, from the structural to the transduction pathway level. We expect this work may guide the design of further experiments to obtain a comprehensive view for the neuropharmacological role of these interacting receptors.This article is part of the Special Issue on "The receptor-receptor interaction as a new target for therapy".
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.neuropharm.2023.109574
dc.identifier.eissn1873-7064
dc.identifier.issn0028-3908
dc.identifier.urihttps://doi.org/10.1016/j.neuropharm.2023.109574
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92061
dc.identifier.wosidWOS:001010668400001
dc.language.isoen
dc.revistaNeuropharmacology
dc.rightsacceso restringido
dc.subjectCrosstalking
dc.subjectProtein -protein interaction
dc.subject5-HT 3A receptor
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCrosstalking interactions between P2X4 and 5-HT3A receptors
dc.typeartículo
dc.volumen236
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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