First-trimester pregnancy loss and active <i>Chlamydia</i> <i>trachomatis</i> infection

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dc.contributor.authorVigil, P
dc.contributor.authorTapia, A
dc.contributor.authorZacharias, S
dc.contributor.authorRiquelme, R
dc.contributor.authorSalgado, AM
dc.contributor.authorVarleta, J
dc.date.accessioned2025-01-21T01:10:09Z
dc.date.available2025-01-21T01:10:09Z
dc.date.issued2002
dc.description.abstractThe incidence of Chlamydia trachomatis (Ct) infection and the possible correlation between couples presenting with first-trimester spontaneous abortions and active Ct infection was assessed. Additionally, the ability of Ct to infect zona-free hamster oocytes was explored by incubating the oocytes with spermatozoa from infected patients. A total of 961 women and 750 men consulting our reproductive medicine centre were screened for Ct using direct immunofluorescence. The general incidence of Ct infection was 9.4% in females ( 90 of 961) and 13.9% in males ( 104 of 750). In women with spontaneous abortions the incidence of Ct was 21.0% ( 14 of 66) compared with 8.9% ( 23 of 59) for women without spontaneous abortions and term pregnancies (chi-square, P < 0.05). When both partners of the couples were considered ( one or both partners infected), the incidence rose to 68.8% ( 22 of 32) (chi-square, P < 0.001). In vitro studies using electron microscopy demonstrated the presence of Ct on the surface of and inside the oocyte. These results indicate a correlation between an active Ct infection and spontaneous abortion. Electron microscopy studies suggested the possibility of direct oocyte infection by Ct. Two models are proposed for the pathogenesis of Ct-related early abortions: ( i) direct zygote infection, and (ii) immune response to heat shock proteins expressed by the zygote and triggered by previous Ct infections.
dc.fuente.origenWOS
dc.identifier.issn0303-4569
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96655
dc.identifier.wosidWOS:000179648900005
dc.issue.numero6
dc.language.isoen
dc.pagina.final378
dc.pagina.inicio373
dc.revistaAndrologia
dc.rightsacceso restringido
dc.subjectChlamydia trachomatis
dc.subjecthamster oocyte
dc.subjecthuman spermatozoa
dc.subjectspontaneous abortion
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFirst-trimester pregnancy loss and active <i>Chlamydia</i> <i>trachomatis</i> infection
dc.typeartículo
dc.volumen34
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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