Synthesis and <i>in Vitro</i> Antiproliferative Activity of New Phenylaminoisoquinolinequinones against Cancer Cell Lines

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dc.contributor.authorDelgado, Virginia
dc.contributor.authorIbacache, Andrea
dc.contributor.authorArancibia, Veronica
dc.contributor.authorTheoduloz, Cristina
dc.contributor.authorValderrama, Jaime A.
dc.date.accessioned2025-01-24T00:05:17Z
dc.date.available2025-01-24T00:05:17Z
dc.date.issued2013
dc.description.abstractA variety of phenylaminoisoquinolinequinones were synthesized and tested for their antiproliferative activity against three human-tumor derived cancer cell lines. The new aminoquinones were prepared from 4-methoxycarbonyl-3-methylisoquinoline-5,8-quinone (1) via acid-induced amination and bromination reactions. Remarkable differences in antiproliferative activity were observed depending upon the location and donor capacity of the substituted phenylamino group at the quinone nucleus. The effect of the substituents on the biological activity is discussed in terms of the donor-acceptor interactions which were evaluated through the redox properties of the aminoquinones.
dc.fuente.origenWOS
dc.identifier.doi10.3390/molecules18010721
dc.identifier.eissn1420-3049
dc.identifier.urihttps://doi.org/10.3390/molecules18010721
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101829
dc.identifier.wosidWOS:000314032900045
dc.issue.numero1
dc.language.isoen
dc.pagina.final734
dc.pagina.inicio721
dc.revistaMolecules
dc.rightsacceso restringido
dc.subjectphenylaminoisoquinoline-5,8-quinones
dc.subjectregioselectivity
dc.subjecthalf-wave potential
dc.subjectantiproliferative activity
dc.subjectSAR analysis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynthesis and <i>in Vitro</i> Antiproliferative Activity of New Phenylaminoisoquinolinequinones against Cancer Cell Lines
dc.typeartículo
dc.volumen18
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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