Diagnostic Performance of First Trimester Screening of Preeclampsia Based on Uterine Artery Pulsatility Index and Maternal Risk Factors in Routine Clinical Use

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dc.contributor.authorMonckeberg, Max
dc.contributor.authorArias, Valentina
dc.contributor.authorFuenzalida, Rosario
dc.contributor.authorAlvarez, Santiago
dc.contributor.authorToro, Victoria
dc.contributor.authorCalvo, Andres
dc.contributor.authorKusanovic, Juan P.
dc.contributor.authorMonteiro, Lara J.
dc.contributor.authorSchepeler, Manuel
dc.contributor.authorNien, Jyh K.
dc.contributor.authorMartinez, Jaime
dc.contributor.authorIllanes, Sebastian E.
dc.date.accessioned2025-01-23T19:51:51Z
dc.date.available2025-01-23T19:51:51Z
dc.date.issued2020
dc.description.abstractPreeclampsia is a pregnancy-specific disorder defined by new onset of hypertension and proteinuria after 20 weeks of gestation. The early detection of patients at risk of developing preeclampsia is crucial, however, predictive models are still controversial. We aim to evaluate the diagnostic performance of a predictive algorithm in the first trimester of pregnancy, in order to identify patients that will subsequently develop preeclampsia, and to study the effect of aspirin on reducing the rate of this complication in patients classified as high risk by this algorithm. A retrospective cohort including 1132 patients attending prenatal care at Clinica Davila in Santiago, Chile, was conceived. The risk of developing preeclampsia (early and late onset) was calculated using algorithms previously described by Plasencia et al. Patients classified as high risk, in the first trimester of pregnancy, by these algorithms, were candidates to receive 100 mg/daily aspirin as prophylaxis at the discretion of the attending physician. The overall incidence of preeclampsia in this cohort was 3.5% (40/1132), and the model for early onset preeclampsia prediction detected 33% of patients with early onset preeclampsia. Among the 105 patients considered at high risk of developing preeclampsia, 56 received aspirin and 49 patients did not. Among those who received aspirin, 12% (7/56) developed preeclampsia, which is equal to the rate of preeclampsia (12% (6/49)) of those who did not receive this medication. Therefore, the diagnostic performance of an algorithm combining uterine artery Doppler and maternal factors in the first trimester predicted only one third of patients that developed preeclampsia. Among those considered at high risk for developing the disease using this algorithm, aspirin did not change the incidence of preeclampsia, however, this could be due either to the small study sample size or the type of the study, a retrospective, non-interventional cohort study.
dc.description.funderUniversidad de los Andes
dc.fuente.origenWOS
dc.identifier.doi10.3390/diagnostics10040182
dc.identifier.eissn2075-4418
dc.identifier.urihttps://doi.org/10.3390/diagnostics10040182
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100603
dc.identifier.wosidWOS:000534251000058
dc.issue.numero4
dc.language.isoen
dc.revistaDiagnostics
dc.rightsacceso restringido
dc.subjectpreeclampsia
dc.subjectuterine artery Doppler
dc.subjectultrasound
dc.subjectgestational hypertension
dc.subjectearly prediction
dc.subjectaspirin
dc.subjectpredictive algorithm
dc.subjectroutine care
dc.subjectprenatal care
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleDiagnostic Performance of First Trimester Screening of Preeclampsia Based on Uterine Artery Pulsatility Index and Maternal Risk Factors in Routine Clinical Use
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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