Hydrofluoroether Synthesis through One-Pot Anodic Iodoalkoxylation of Alkenes

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dc.contributor.authorBecerra-Ruiz, Martin
dc.contributor.authorWinterson, Bethan
dc.contributor.authorPerez, Edwin G.
dc.contributor.authorWirth, Thomas
dc.date.accessioned2025-01-20T16:04:25Z
dc.date.available2025-01-20T16:04:25Z
dc.date.issued2024
dc.description.abstractThe incorporation of carbon-fluorine bonds can profoundly influence the chemical and physical properties of drugs, agrochemicals, and materials. Different methods allow the installation of CF3, CF2H units and C-F bonds including trifluoro- and difluoromethoxylations, reflecting the limited diversity of reactions available to synthetic chemists. We introduce the 2,2,2-trifluoroethoxy group through an electro-oxidative iodination of alkenes as a versatile substituent for fluorine chemists. An iodoarene serves as an unusual iodine source facilitating the 1,2-iodoalkoxylation of a broad range of industrially relevant aliphatic alkenes in high yields (31-98%) showing high Markovnikov regioselectivity.
dc.fuente.origenWOS
dc.identifier.doi10.1002/adsc.202401108
dc.identifier.eissn1615-4169
dc.identifier.issn1615-4150
dc.identifier.urihttps://doi.org/10.1002/adsc.202401108
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89747
dc.identifier.wosidWOS:001356810400001
dc.language.isoen
dc.revistaAdvanced synthesis & catalysis
dc.rightsacceso restringido
dc.subjectElectrochemistry
dc.subjectHydrofluoroethers
dc.subjectHypervalent iodine
dc.subjectIodination
dc.subject2,2,2-trifluoroethoxy
dc.titleHydrofluoroether Synthesis through One-Pot Anodic Iodoalkoxylation of Alkenes
dc.typeartículo
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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