Involvement of MT1-MMP and TIMP-2 in human periodontal disease

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dc.contributor.authorOyarzun, A.
dc.contributor.authorArancibia, R.
dc.contributor.authorHidalgo, R.
dc.contributor.authorPenafiel, C.
dc.contributor.authorCaceres, M.
dc.contributor.authorGonzalez, M J
dc.contributor.authorMartinez, J.
dc.contributor.authorSmith, P. C.
dc.date.accessioned2024-01-10T13:14:07Z
dc.date.available2024-01-10T13:14:07Z
dc.date.issued2010
dc.description.abstractObjectives:
dc.description.abstractPeriodontal disease is characterized by an increased collagen metabolism. Although membrane type-1 matrix metalloproteinase (MT1-MMP) plays a critical role in collagen degradation, its involvement in human periodontitis remains to be determined.
dc.description.abstractMethods:
dc.description.abstractMT1-MMP and TIMP-2 expression and distribution were evaluated in gingival tissue samples derived from 10 healthy and 12 periodontitis-affected human subjects. MT1-MMP and TIMP-2 expression were assessed through Western-blot of tissue homogenates. The main cell types involved in MT1-MMP and TIMP-2 production were evaluated by means of immunohistochemistry.
dc.description.abstractResults:
dc.description.abstractBoth MT1-MMP and TIMP-2 were significantly increased in periodontitis-affected gingival tissues when compared to healthy gingiva. Moreover, the balance between MT1-MMP and its inhibitor TIMP-2 was altered in periodontitis-affected tissues, suggesting an imbalance in this proteolytic axis. Immunohistochemistry demonstrated the expression of MT1-MMP in fibroblasts and macrophages in gingival tissues. MT1-MMP was detected in cells in close association with the gingival collagen matrix. TIMP-2 expression was identified in fibroblasts, macrophages and epithelial cells.
dc.description.abstractConclusions:
dc.description.abstractOur observations show an increased expression of MT1-MMP and TIMP-2 in periodontitis-affected gingival tissues. The altered balance between these two molecular mediators of collagen remodeling suggests their involvement in human periodontal disease.
dc.description.funderNational Fund for Science and Technology from Chile
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1601-0825.2009.01651.x
dc.identifier.eissn1601-0825
dc.identifier.issn1354-523X
dc.identifier.pubmedidMEDLINE:20233321
dc.identifier.urihttps://doi.org/10.1111/j.1601-0825.2009.01651.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78374
dc.identifier.wosidWOS:000276247800011
dc.information.autorucMedicina;Arancibia R;S/I;1006668
dc.information.autorucMedicina;Smith PC;S/I;1006488
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final395
dc.pagina.inicio388
dc.publisherWILEY
dc.revistaORAL DISEASES
dc.rightsacceso restringido
dc.subjectMMP
dc.subjectMMP-14
dc.subjectMT1-MMP
dc.subjectTIMP-2
dc.subjectperiodontal disease
dc.subjectTYPE-1 MATRIX-METALLOPROTEINASE
dc.subjectGINGIVAL CREVICULAR FLUID
dc.subjectNECROSIS-FACTOR-ALPHA
dc.subject1-MATRIX METALLOPROTEINASE
dc.subjectTISSUE INHIBITOR
dc.subjectIN-VIVO
dc.subjectEXPRESSION
dc.subjectCOLLAGENASE
dc.subjectACTIVATION
dc.subjectSURFACE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInvolvement of MT1-MMP and TIMP-2 in human periodontal disease
dc.typeartículo
dc.volumen16
sipa.codpersvinculados1006668
sipa.codpersvinculados1006488
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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