Immune checkpoints and the regulation of tolerogenicity in dendritic cells: Implications for autoimmunity and immunotherapy.

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dc.catalogadorpau
dc.contributor.authorFunes, Samanta C.
dc.contributor.authorManrique de Lara, Amaranta
dc.contributor.authorAltamirano-Lagos, María J.
dc.contributor.authorMackern-Oberti, Juan P.
dc.contributor.authorEscobar-Vera, Jorge
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-03-06T14:05:53Z
dc.date.available2024-03-06T14:05:53Z
dc.date.issued2019
dc.description.abstractThe immune system is responsible for defending the host from a large variety of potential pathogens, while simultaneously avoiding immune reactivity towards self-components. Self-tolerance has to be tightly maintained throughout several central and peripheral processes; immune checkpoints are imperative for regulating the immunity/tolerance balance. Dendritic cells (DCs) are specialized cells that capture antigens, and either activate or inhibit antigen-specific T cells. Therefore, they play a key role at inducing and maintaining immune tolerance. DCs that suppress the immune response have been called tolerogenic dendritic cells (tolDCs). Given their potential as a therapy to prevent transplant rejection and autoimmune damage, several strategies are under development to generate tolDCs, in order to avoid activation and expansion of self-reactive T cells. In this article, we summarize the current knowledge relative to the main features of tolDCs, their mechanisms of action and their therapeutic use for autoimmune diseases. Based on the literature reviewed, autologous antigen-specific tolDCs might constitute a promising strategy to suppress autoreactive T cells and reduce detrimental inflammatory processes.
dc.fechaingreso.objetodigital2024-03-05
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.autrev.2019.02.006
dc.identifier.urihttps://doi.org/10.1016/j.autrev.2019.02.006
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84252
dc.information.autorucEscuela de Medicina; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.language.isoen
dc.nota.accesoContenido parcial
dc.rightsacceso restringido
dc.titleImmune checkpoints and the regulation of tolerogenicity in dendritic cells: Implications for autoimmunity and immunotherapy.
dc.typeartículo
sipa.codpersvinculados90610
sipa.trazabilidadORCID;2024-01-15
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