Impact of common cardio metabolic risk factors on fatal and non fatal cardiovascular disease in Latin America and the Caribbean: an individual level pooled analysis of 31 cohort studies

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dc.article.number100068
dc.catalogadoryvc
dc.contributor.authorCarrillo-Larco, Rodrigo M.
dc.contributor.authorStern, Dalia
dc.contributor.authorHambleton, Ian
dc.contributor.authorHennis, Anselm
dc.contributor.authorCesare, Mariachiara Di
dc.contributor.authorLotufo, Paulo
dc.contributor.authorFerreccio Readi, Fresia Catterina
dc.contributor.authorIrazola, Vilma
dc.contributor.authorPerel, Pablo
dc.contributor.authorGregg, Edward W.
dc.contributor.authorMiranda, J. Jaime
dc.contributor.authorEzzati, Majid
dc.contributor.authorGoodarz, Danaei
dc.contributor.authorAguilar-Salinas, Carlos A.
dc.contributor.authorAlvarez-Váz, Ramón
dc.contributor.authorMarselle B., Amadio
dc.contributor.authorBaccino, Cecilia
dc.contributor.authorBambs Sandoval, Claudia Elena
dc.contributor.authorBastos, Joao Luiz
dc.contributor.authorCortés Arancibia, Sandra Isabel
dc.contributor.otherCohorts Consortium of Latin America and the Caribbean (CC-LAC)
dc.date.accessioned2024-01-08T20:41:02Z
dc.date.available2024-01-08T20:41:02Z
dc.date.issued2021
dc.description.abstractBackground: estimates of the burden of cardio-metabolic risk factors in Latin America and the Caribbean (LAC) rely on relative risks (RRs) from non-LAC countries. Whether these RRs apply to LAC remains unknown. Methods: We pooled LAC cohorts. We estimated RRs per unit of exposure to body mass index (BMI), systolic blood pressure (SBP), fasting plasma glucose (FPG), total cholesterol (TC) and non-HDL cholesterol on fatal (31 cohorts, n=168,287) and non-fatal (13 cohorts, n=27,554) cardiovascular diseases, adjusting for regression dilution bias. We used these RRs and national data on mean risk factor levels to estimate the number of cardiovascular deaths attributable to non-optimal levels of each risk factor. Results: Our RRs for SBP, FPG and TC were like those observed in cohorts conducted in high-income countries; however, for BMI, our RRs were consistently smaller in people below 75 years of age. Across risk factors, we observed smaller RRs among older ages. Non-optimal SBP was responsible for the largest number of attributable cardiovascular deaths ranging from 38 per 100,000 women and 54 men in Peru, to 261 (Dominica, women) and 282 (Guyana, men). For non-HDL cholesterol, the lowest attributable rate was for women in Peru (21) and men in Guatemala (25), and the largest in men (158) and women (142) from Guyana. Interpretation: RRs for BMI from studies conducted in high-income countries may overestimate disease burden metrics in LAC; conversely, RRs for SBP, FPG and TC from LAC cohorts are similar to those estimated from cohorts in high-income countries. Funding: Wellcome Trust (214185/Z/18/Z)
dc.description.funderWellcome Trust (214185/Z/18/Z)
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.lana.2021.100068
dc.identifier.eissn2667-193X
dc.identifier.scopusidSCOPUS_ID:85132818523
dc.identifier.urihttps://doi.org/10.1016/j.lana.2021.100068
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75661
dc.identifier.urihttps://www.journals.elsevier.com/the-lancet-regional-health-americas
dc.information.autorucEscuela de Medicina; Ferreccio Readi, Fresia Catterina; 0000-0001-6331-5534; 99684
dc.information.autorucEscuela de Medicina; Bambs Sandoval, Claudia Elena; 0000-0002-7043-6833; 89631
dc.information.autorucEscuela de Medicina; Cortés Arancibia Sandra Isabel; 0000-0003-3293-1419; 1005970
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherElsevier Ltd
dc.revistaThe Lancet Regional Health - Americas
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/
dc.titleImpact of common cardio metabolic risk factors on fatal and non fatal cardiovascular disease in Latin America and the Caribbean: an individual level pooled analysis of 31 cohort studies
dc.typeartículo
dc.volumen4
sipa.codpersvinculados99684
sipa.codpersvinculados89631
sipa.codpersvinculados1005970
sipa.trazabilidadSCOPUS;2022-07-08
sipa.trazabilidadORCID;2024-01-07
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