Lentigo maligna and lentigo maligna melanoma in patients younger than 50 years: a multicentre international clinical-dermoscopic study

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dc.contributor.authorLongo, Caterina
dc.contributor.authorSticchi, Alberto
dc.contributor.authorCurti, Alex
dc.contributor.authorKaleci, Shaniko
dc.contributor.authorMoscarella, Elvira
dc.contributor.authorArgenziano, Giuseppe
dc.contributor.authorThomas, Luc
dc.contributor.authorGuitera, Pascale
dc.contributor.authorHuang, Chen
dc.contributor.authorTiodorovic, Danica
dc.contributor.authorApalla, Zoe
dc.contributor.authorPeris, Ketty
dc.contributor.authordel Regno, Laura
dc.contributor.authorGuida, Stefania
dc.contributor.authorLallas, Aimilios
dc.contributor.authorKittler, Harald
dc.contributor.authorPellacani, Giovanni
dc.contributor.authorNavarrete-Dechent, Cristian
dc.date.accessioned2025-01-20T17:11:22Z
dc.date.available2025-01-20T17:11:22Z
dc.date.issued2024
dc.description.abstractBackground Lentigo maligna/lentigo maligna melanoma (LM/LMM) is usually diagnosed in older patients, when lesions are larger. However, it is important to detect it at an earlier stage to minimize the area for surgical procedure.
dc.description.abstractObjectives To determine and define clinical, dermoscopic and reflectance confocal microscopy (RCM) features of LM/LMM in patients < 50 years old.
dc.description.abstractMethods This was a multicentre study involving tertiary referral centres for skin cancer management. The study included cases of consecutively excised LM/LMM arising in patients < 50 years of age with a histopathological diagnosis of LM/LMM and a complete set of clinical and dermoscopic images; RCM images were considered when present.
dc.description.abstractResults In total, 85 LM/LMM of the face from 85 patients < 50 years were included in the study. A regression model showed a direct association with the size of the lesion (R-2 = 0.08; P = 0.01) and with the number of dermoscopic features at diagnosis (R-2 = 0.12; P < 0.01). In a multivariable analysis, an increasing number of dermoscopic features correlated with increased patient age (P < 0.01), while the presence of grey colour was a predictor of younger age at diagnosis (P = 0.03). RCM revealed the presence of melanoma diagnostic features in all cases (pagetoid cells and atypical nesting).
dc.description.abstractConclusions LM is not a disease limited to older people as previously thought. LM presenting in young adults tends to be smaller and with fewer dermoscopic features, making its diagnosis challenging. Careful evaluation of facial pigmented lesions prior to cosmetic procedures is imperative to avoid incorrectly treating early LM as a benign lesion.
dc.description.funderWe want to thank our patients and their families, who are the main reason for our studies.
dc.fuente.origenWOS
dc.identifier.doi10.1093/ced/llad325
dc.identifier.eissn1365-2230
dc.identifier.issn0307-6938
dc.identifier.urihttps://doi.org/10.1093/ced/llad325
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91178
dc.identifier.wosidWOS:001105762300001
dc.issue.numero2
dc.language.isoen
dc.pagina.final134
dc.pagina.inicio128
dc.revistaClinical and experimental dermatology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLentigo maligna and lentigo maligna melanoma in patients younger than 50 years: a multicentre international clinical-dermoscopic study
dc.typeartículo
dc.volumen49
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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