Muc1 and glycan expression in the oviduct and endometrium of a new world monkey, Cebus apella

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dc.contributor.authorJones, CJP
dc.contributor.authorOrtiz, ME
dc.contributor.authorCroxatto, HB
dc.contributor.authorManzur, A
dc.contributor.authorSlevin, G
dc.contributor.authorAplin, JD
dc.date.accessioned2024-01-10T12:06:48Z
dc.date.available2024-01-10T12:06:48Z
dc.date.issued2001
dc.description.abstractCebus apella is a New World monkey that has a menstrual cycle of 18-23 days with implantation at approximately luteal Day 5, The aim of this study was to characterize by lectin- and antibody-labeling the distribution of Mud and associated glycans on the endometrial and oviductal epithelium during the luteal phase of the cycle, Endometrial histology showed a thin endometrium, with glands extending deeply into the myometrium, No obvious evidence of secretory differentiation in cells of either the superficial or the basal segments of glands could be obtained using a panel of antibodies and lectins that marked epithelial glycoprotein, and glycosylation changes observed in some other primate endometrial cycles were not observed in this study, Antibodies to human MUC1 were shown to cross-react with C, apella, and Mud was localized to the apical epithelial surfaces of both the endometrial and the tubal epithelium, with stronger expression in the latter. Again, no cyclic changes were noted, Antibodies specific to the isoform Muc1/Sec showed strong staining at the apical tubal epithelium, but no reactivity was detectable in the luminal epithelium of the uterus. This observation suggests differences between the two glycocalyces and could help to explain why C, apella embryos do not implant in this location.
dc.fechaingreso.objetodigital2024-05-02
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1095/biolreprod64.5.1535
dc.identifier.eissn1529-7268
dc.identifier.issn0006-3363
dc.identifier.pubmedidMEDLINE:11319162
dc.identifier.urihttps://doi.org/10.1095/biolreprod64.5.1535
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76208
dc.identifier.wosidWOS:000168364800032
dc.information.autorucMedicina;Manzur A;S/I;57590
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1544
dc.pagina.inicio1535
dc.publisherOXFORD UNIV PRESS INC
dc.revistaBIOLOGY OF REPRODUCTION
dc.rightsacceso restringido
dc.subjectimplantation
dc.subjectmonkey
dc.subjectMuc1
dc.subjectoviduct
dc.subjectuterus
dc.subjectKERATAN SULFATE
dc.subjectBINDING
dc.subjectGLYCOSYLATION
dc.subjectEPITHELIUM
dc.subjectMODULATION
dc.subjectPREGNANCY
dc.subjectINTEGRIN
dc.subjectPHASE
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleMuc1 and glycan expression in the oviduct and endometrium of a new world monkey, Cebus apella
dc.typeartículo
dc.volumen64
sipa.codpersvinculados57590
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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