Optimal length of triple therapy for H pylori eradication in a population with high prevalence of infection in Chile

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dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorSoza, Alejandro
dc.contributor.authorPedreros, Cesar
dc.contributor.authorBustamante, Andrea
dc.contributor.authorValenzuela, Felipe
dc.contributor.authorOtarola, Francisco
dc.contributor.authorAbbott, Eduardo
dc.contributor.authorArellano, Marco
dc.contributor.authorMedina, Brenda
dc.contributor.authorPattillo, Alejandro
dc.contributor.authorGreig, Douglas
dc.contributor.authorArrese, Marco
dc.contributor.authorRollan, Antonio
dc.date.accessioned2024-01-10T13:15:58Z
dc.date.available2024-01-10T13:15:58Z
dc.date.issued2007
dc.description.abstractAIM: To compare the efficacy of 7-d versus 14-d triple therapy for the treatment of H pylori infection in Chile, with a prevalence of 73% in general population. METHODS: H pylori-infected patients diagnosed by rapid urease test, with non-ulcer dyspepsia or peptic ulcer disease were randomized to receive omeprazole 20 mg bid, amoxicillin 1 g bid, and clarithromycin 500 mg bid for 7 (OAC7) or 14 (OAC14) d. Primary outcome was eradication rate 6 wk after the treatment. Subgroup analysis was carried out considering the eradication rate among patients with or without peptic ulcer disease and eradication rate among smokers or non-smokers.
dc.description.abstractRESULTS: One hundred and thirty-one patients were randomized to OAC7 (n = 69) or OAC14 (n = 62). The overall eradication rate (intention-to-treat) was 78.3% in OAC7 and 85.5% in OAC14 groups, without a significant difference (P = 0.37). No significant difference in the eradication rate was found among the patients with peptic ulcer disease (n = 31) between the OAC7 group (85.7%) and OAC14 group (87.5%). However, smokers had an obviously lower eradication rate compared to non-smokers, particularly in the OAC7 group (57.1% in smokers vs 83.6% in non-smokers; P = 0.06). Adverse effects rate were similar between both groups.
dc.description.abstractCONCLUSION: Short-term efficacy of triple therapy with OAC for 7 d is comparable to 14 d in this high-prevalence population. Longer follow-up, and studies focused to some subgroups of patients (smokers and non-ulcer patients) are necessary to support widespread use of 7-d instead of 10-14-d triple therapy in a developing country like Chile. (C) 2007 The WJG Press. All rights reserved.
dc.fechaingreso.objetodigital2024-05-27
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3748/wjg.v13.i21.2967
dc.identifier.eissn2219-2840
dc.identifier.issn1007-9327
dc.identifier.pubmedidMEDLINE:17589948
dc.identifier.urihttps://doi.org/10.3748/wjg.v13.i21.2967
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78547
dc.identifier.wosidWOS:000247385700011
dc.information.autorucMedicina;Arrese M;S/I;76095
dc.information.autorucMedicina;Greig D;S/I;15418
dc.information.autorucMedicina;Riquelme A;S/I;3538
dc.information.autorucMedicina;Rollan A;S/I;100118
dc.information.autorucMedicina;Soza A;S/I;461
dc.issue.numero21
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final2972
dc.pagina.inicio2967
dc.publisherBAISHIDENG PUBLISHING GROUP INC
dc.revistaWORLD JOURNAL OF GASTROENTEROLOGY
dc.rightsacceso abierto
dc.subjectHelicobacter pylori
dc.subjectantibiotic treatment
dc.subjectomeprazole
dc.subjectamoxicillin
dc.subjectclarithromycin
dc.subjectquasi-randomized controlled trial
dc.subjectDUODENAL-ULCER DISEASE
dc.subjectREINFECTION RATE
dc.subjectRISK-FACTORS
dc.subjectDOUBLE-BLIND
dc.subjectAMOXICILLIN
dc.subjectLANSOPRAZOLE
dc.subjectCLARITHROMYCIN
dc.subjectMULTICENTER
dc.subjectOMEPRAZOLE
dc.subjectMANAGEMENT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOptimal length of triple therapy for H pylori eradication in a population with high prevalence of infection in Chile
dc.typeartículo
dc.volumen13
sipa.codpersvinculados76095
sipa.codpersvinculados15418
sipa.codpersvinculados3538
sipa.codpersvinculados100118
sipa.codpersvinculados461
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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