LINC00662 Promotes Aggressive Traits by Modulating OCT4 Expression through miR-335-5p in Gallbladder Cancer Cells

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dc.catalogadorgrr
dc.contributor.authorPerez-Moreno, Pablo
dc.contributor.authorRiquelme, Ismael
dc.contributor.authorBizama Soto, Carolina Del Carmen
dc.contributor.authorVergara-Gomez, Luis
dc.contributor.authorTapia, Julio C.
dc.contributor.authorBrebi, Priscilla
dc.contributor.authorGarcia Canete, Patricia Del Carmen
dc.contributor.authorRoa Strauch, Juan Carlos Enrique
dc.date.accessioned2024-07-19T14:14:35Z
dc.date.available2024-07-19T14:14:35Z
dc.date.issued2024
dc.description.abstractLong non-coding RNAs (lncRNAs) are nucleotide sequences that participate in different biological processes and are associated with different pathologies, including cancer. Long intergenic non-protein-coding RNA 662 (LINC00662) has been reported to be involved in different cancers, including colorectal, prostate, and breast cancer. However, its role in gallbladder cancer has not yet been described. In this article, we hypothesize that LINC00662 has an important role in the acquisition of aggressiveness traits such as a stem-like phenotype, invasion, and chemoresistance in gallbladder cancer. Here, we show that LINC00662 is associated with larger tumor size and lymph node metastasis in patients with gallbladder cancer. Furthermore, we show that the overexpression of LINC00662 promotes an increase in CD133+/CD44+ cell populations and the expression of stemness-associated genes. LINC00662 promotes greater invasive capacity and the expression of genes associated with epithelial-mesenchymal transition. In addition, the expression of LINC00662 promotes resistance to cisplatin and 5-fluorouracil, associated with increased expression of chemoresistance-related ATP-binding cassette (ABC) transporters in gallbladder cancer (GBC) cell lines. Finally, we show that the mechanism by which LINC00662 exerts its function is through a decrease in microRNA 335-5p (miR-335-5p) and an increase in octamer-binding transcription factor 4 (OCT4) in GBC cells. Thus, our data allow us to propose LINC00662 as a biomarker of poor prognosis and a potential therapeutic target for patients with GBC.
dc.fechaingreso.objetodigital2024-07-19
dc.fuente.origenORCID
dc.identifier.doi10.3390/ijms25126740
dc.identifier.eissn1422-0067
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.pubmedid38928444
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85197193093
dc.identifier.urihttps://doi.org/10.3390/ijms25126740
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87168
dc.identifier.wosidWOS:001255942400001
dc.information.autorucEscuela de Medicina; Bizama Soto, Carolina Del Carmen; 0000-0002-5379-6191; 237745
dc.information.autorucEscuela de Medicina; Garcia Canete, Patricia Del Carmen; 0000-0002-3817-4896; 73909
dc.information.autorucEscuela de Medicina; Roa Strauch, Juan Carlos Enrique; 0000-0001-8313-8774; 84743
dc.issue.numero12
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherMDPI
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.rights.licenseATTRIBUTION 4.0 INTERNATIONAL
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectLINC00662
dc.subjectGallbladder cancer
dc.subjectmiR-335-5p
dc.subjectOCT4
dc.subject.ddc500
dc.subject.deweyCienciases_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLINC00662 Promotes Aggressive Traits by Modulating OCT4 Expression through miR-335-5p in Gallbladder Cancer Cells
dc.typeartículo
dc.volumen25
sipa.codpersvinculados237745
sipa.codpersvinculados73909
sipa.codpersvinculados84743
sipa.trazabilidadWOS;2024-07-13
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