Development of a Compartmental Pharmacokinetic Model for Molecular Radiotherapy with <SUP>131</SUP>I-CLR1404

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dc.contributor.authorNeira, Sara
dc.contributor.authorGago-Arias, Araceli
dc.contributor.authorGonzalez-Crespo, Isabel
dc.contributor.authorGuiu-Souto, Jacobo
dc.contributor.authorPardo-Montero, Juan
dc.date.accessioned2025-01-20T22:07:43Z
dc.date.available2025-01-20T22:07:43Z
dc.date.issued2021
dc.description.abstractPharmacokinetic modeling of the radiopharmaceuticals used in molecular radiotherapy is an important step towards accurate radiation dosimetry of such therapies. In this paper, we present a pharmacokinetic model for CLR1404, a phospholipid ether analog that, labeled with I-124/I-131, has emerged as a promising theranostic agent. We follow a systematic approach for the model construction based on a decoupling process applied to previously published experimental data, and using the goodness-of-fit, Sobol's sensitivity analysis, and the Akaike Information Criterion to construct the optimal form of the model, investigate potential simplifications, and study factor prioritization. This methodology was applied to previously published experimental human time-activity curves for 9 organs. The resulting model consists of 17 compartments involved in the CLR1404 metabolism. Activity dynamics in most tissues are well described by a blood contribution plus a two-compartment system, describing fast and slow uptakes. The model can fit both clinical and pre-clinical kinetic data of I-124/I-131. In addition, we have investigated how simple fits (exponential and biexponential) differ from the complete model. Such fits, despite providing a less accurate description of time-activity curves, may be a viable alternative when limited data is available in a practical case.
dc.fuente.origenWOS
dc.identifier.doi10.3390/pharmaceutics13091497
dc.identifier.eissn1999-4923
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics13091497
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94255
dc.identifier.wosidWOS:000701923900001
dc.issue.numero9
dc.language.isoen
dc.revistaPharmaceutics
dc.rightsacceso restringido
dc.subjectbiokinetics
dc.subjectcompartmental model
dc.subjectiodine
dc.subjectmolecular radiotherapy
dc.subjectCLR1404
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDevelopment of a Compartmental Pharmacokinetic Model for Molecular Radiotherapy with <SUP>131</SUP>I-CLR1404
dc.typeartículo
dc.volumen13
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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