Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology

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dc.contributor.authorTrigatti, B
dc.contributor.authorRayburn, H
dc.contributor.authorVinals, M
dc.contributor.authorBraun, A
dc.contributor.authorMiettinen, H
dc.contributor.authorPenman, M
dc.contributor.authorHertz, M
dc.contributor.authorSchrenzel, M
dc.contributor.authorAmigo, L
dc.contributor.authorRigotti, A
dc.contributor.authorKrieger, M
dc.date.accessioned2024-01-10T12:06:04Z
dc.date.available2024-01-10T12:06:04Z
dc.date.issued1999
dc.description.abstractThe high density lipoprotein (HDL) receptor SR-BI (scavenger receptor class B type I) mediates the selective uptake of plasma HDL cholesterol by the liver and steroidogenic tissues. As a consequence, SR-BI can influence plasma HDL cholesterol levels, HDL structure, biliary cholesterol concentrations, and the uptake, storage, and utilization of cholesterol by steroid hormone-producing cells. Here we used homozygous null SR-BI knockout mice to show that SR-BI is required for maintaining normal biliary cholesterol levels, oocyte development, and female fertility. We also used SR-BI/apolipoprotein E double homozygous knockout mice to show that SR-BI can protect against early-onset atherosclerosis. Although the mechanisms underlying the effects of SR-BI loss on reproduction and atherosclerosis have not been established, potential causes include changes in (i) plasma lipoprotein levels and/or structure, (ii) cholesterol flux into or out of peripheral tissues (ovary, aortic wall), and (iii) reverse cholesterol transport, as indicated by the significant reduction of gallbladder bile cholesterol levels in SR-BI and SR-BI/apolipoprotein E double knockout mice relative to controls. If SR-BI has similar activities in humans, it may become an attractive target for therapeutic intervention in a variety of diseases.
dc.description.funderNHLBI NIH HHS
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.fechaingreso.objetodigital2024-05-06
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1073/pnas.96.16.9322
dc.identifier.issn0027-8424
dc.identifier.pubmedidMEDLINE:10430941
dc.identifier.urihttps://doi.org/10.1073/pnas.96.16.9322
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76111
dc.identifier.wosidWOS:000081835500099
dc.information.autorucMedicina;Rigotti A;S/I;68489
dc.issue.numero16
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final9327
dc.pagina.inicio9322
dc.publisherNATL ACAD SCIENCES
dc.revistaPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
dc.rightsacceso restringido
dc.subjectAPOLIPOPROTEIN-A-I
dc.subjectCHOLESTEROL ACYLTRANSFERASE GENE
dc.subjectMESSENGER-RNA EXPRESSION
dc.subjectSCAVENGER RECEPTOR
dc.subjectSELECTIVE UPTAKE
dc.subjectADRENAL-GLAND
dc.subjectCELLULAR CHOLESTEROL
dc.subjectSTEROIDOGENIC CELLS
dc.subjectTARGETED MUTATION
dc.subjectHDL METABOLISM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInfluence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology
dc.typeartículo
dc.volumen96
sipa.codpersvinculados68489
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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