Predictive ability of propofol effect-site concentrations during fast and slow infusion rates

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dc.contributor.authorSepulveda, P. O.
dc.contributor.authorCortinez, L. I.
dc.contributor.authorRecart, A.
dc.contributor.authorMunoz, H. R.
dc.date.accessioned2024-01-10T13:16:28Z
dc.date.available2024-01-10T13:16:28Z
dc.date.issued2010
dc.description.abstractBackground
dc.description.abstractThe performance of propofol effect-site pharmacokinetic models during target-controlled infusion (TCI) might be affected by propofol administration rate. This study compares the predictive ability of three effect-site pharmacokinetic models during fast and slow infusion rates, utilizing the cerebral state index (CSI) as a monitor of consciousness.
dc.description.abstractMethods
dc.description.abstractSixteen healthy volunteers, 21-45 years of age, were randomly assigned to receive either a bolus dose of propofol 1.8 mg/kg at a rate of 1200 ml/h or an infusion of 12 mg/kg/h until 3-5 min after loss of consciousness (LOC). After spontaneous recovery of the CSI, the bolus was administered to patients who had first received the infusion and vice versa. The study was completed after spontaneous recovery of CSI following the second dose scheme. LOC was assessed and recorded when it occurred. Adequacies of model predictions during both administration schemes were assessed by comparing the effect-site concentrations estimated at the time of LOC during the bolus dose and during the infusion scheme.
dc.description.abstractResults
dc.description.abstractLOC occurred 0.97 +/- 0.29 min after the bolus dose and 6.77 +/- 3.82 min after beginning the infusion scheme (P < 0.05). The Ce estimated with Schnider (ke0=0.45/min), Marsh (ke0=1.21/min) and Marsh (ke0=0.26/min) at LOC were 4.40 +/- 1.45, 3.55 +/- 0.64 and 1.28 +/- 0.44 mu g/ml during the bolus dose and 2.81 +/- 0.61, 2.50 +/- 0.39 and 1.72 +/- 0.41 mu g/ml, during the infusion scheme (P < 0.05). The CSI values observed at LOC were 70 +/- 4 during the bolus dose and 71 +/- 2 during the infusion scheme (NS).
dc.description.abstractConclusion
dc.description.abstractSpeed of infusion, within the ranges allowed by TCI pumps, significantly affects the accuracy of Ce predictions. The CSI monitor was shown to be a useful tool to predict LOC in both rapid and slow infusion schemes.
dc.fechaingreso.objetodigital2024-05-09
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1399-6576.2009.02183.x
dc.identifier.eissn1399-6576
dc.identifier.issn0001-5172
dc.identifier.pubmedidMEDLINE:20003124
dc.identifier.urihttps://doi.org/10.1111/j.1399-6576.2009.02183.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78587
dc.identifier.wosidWOS:000274932800010
dc.information.autorucMedicina;Cortinez LI;S/I;79356
dc.information.autorucMedicina;Muñoz HR;S/I;73573
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final452
dc.pagina.inicio447
dc.publisherWILEY
dc.revistaACTA ANAESTHESIOLOGICA SCANDINAVICA
dc.rightsacceso restringido
dc.subjectCEREBRAL STATE INDEX
dc.subjectFRONT-END KINETICS
dc.subjectPHARMACOKINETIC MODELS
dc.subjectINDUCTION
dc.subjectPERFORMANCE
dc.subjectANESTHESIA
dc.subjectPLASMA
dc.titlePredictive ability of propofol effect-site concentrations during fast and slow infusion rates
dc.typeartículo
dc.volumen54
sipa.codpersvinculados79356
sipa.codpersvinculados73573
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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