Tetrahydrohyperforin Induces Mitochondrial Dynamics and Prevents Mitochondrial Ca<SUP>2+</SUP> Overload after Aβ and Aβ-AChE Complex Challenge in Rat Hippocampal Neurons

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dc.contributor.authorZolezzi, Juan M.
dc.contributor.authorCarvajal, Francisco J.
dc.contributor.authorRios, Juvenal A.
dc.contributor.authorOrdenes, Daniela
dc.contributor.authorSilva-Alvarez, C.
dc.contributor.authorGodoy, Juan A.
dc.contributor.authorInestrosa, Nibaldo C.
dc.date.accessioned2025-01-24T00:08:07Z
dc.date.available2025-01-24T00:08:07Z
dc.date.issued2013
dc.description.abstractSt. John's wort has been the subject of studies focused on its therapeutic properties against several diseases, including Alzheimer's disease (AD). Amyloid beta-peptide (A beta), a critical peptide in AD, has been linked to the mitochondrial dysfunction often observed in this disease. Despite many efforts to prevent A beta levels from increasing in AD, less has been done regarding the mitochondrial component. Therefore, we studied the effects of tetrahydrohyperforin (THH) on mitochondrial dysfunction of hippocampal neurons, challenged with A beta oligomers (A beta o) and A beta o-AChE complexes. We show that THH prevents mitochondrial calcium overload and induces the modulation of fusion-fission events, arresting mitochondrial dysfunction. Moreover, our results suggest that the modulation of mitochondrial dynamics probably occurs through a peroxisome proliferator-activated receptor gamma co-activator 1 alpha-mediated mechanism, inducing mitochondrial fusion-fission protein expression. Our results offer further explanation for the effects observed for THH and the beneficial effects of this ethno-botanical drug in AD.
dc.fuente.origenWOS
dc.identifier.doi10.3233/JAD-130173
dc.identifier.eissn1875-8908
dc.identifier.issn1387-2877
dc.identifier.urihttps://doi.org/10.3233/JAD-130173
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101947
dc.identifier.wosidWOS:000325649500008
dc.issue.numero4
dc.language.isoen
dc.pagina.final746
dc.pagina.inicio735
dc.revistaJournal of alzheimers disease
dc.rightsacceso restringido
dc.subjectCalcium
dc.subjectDRP1
dc.subjectFIS1
dc.subjectmitochondrial fusion-fission
dc.subjectneurodegeneration
dc.subjectPGC-1 alpha
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTetrahydrohyperforin Induces Mitochondrial Dynamics and Prevents Mitochondrial Ca<SUP>2+</SUP> Overload after Aβ and Aβ-AChE Complex Challenge in Rat Hippocampal Neurons
dc.typeartículo
dc.volumen37
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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