Global epidemiology of alcohol-related liver disease, liver cancer, and alcohol use disorder, 2000–2021

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dc.catalogadordfo
dc.contributor.authorDanpanichkul, Pojsakorn
dc.contributor.authorDíaz Piga, Luis Antonio
dc.contributor.authorSuparan, Kanokphong
dc.contributor.authorTothanarungroj, Primrose
dc.contributor.authorSirimangklanurak, Supapitch
dc.contributor.authorAuttapracha, Thanida
dc.contributor.authorBlaney, Hanna L.
dc.contributor.authorSukphutanan, Banthoon
dc.contributor.authorPang, Yanfang
dc.contributor.authorKongarin, Siwanart
dc.contributor.authorIdalsoaga, Francisco
dc.contributor.authorFuentes-López, Eduardo
dc.contributor.authorLeggio, Lorenzo
dc.contributor.authorNoureddin, Mazen
dc.contributor.authorWhite, Trenton M.
dc.contributor.authorLouvet, Alexandre
dc.contributor.authorMathurin, Philippe
dc.contributor.authorLoomba, Rohit
dc.contributor.authorKamath, Patrick S.
dc.contributor.authorRehm, Jürgen
dc.contributor.authorLazarus, Jeffrey V.
dc.contributor.authorWijarnpreecha, Karn
dc.contributor.authorArab Verdugo, Juan Pablo
dc.date.accessioned2025-04-25T16:47:03Z
dc.date.available2025-04-25T16:47:03Z
dc.date.issued2025
dc.description.abstractBackground/Aims Alcohol represents a leading burden of disease worldwide, including alcohol use disorder (AUD) and alcohol-related liver disease (ALD). We aim to assess the global burden of AUD, ALD, and alcohol-attributable primary liver cancer between 2000–2021. Methods We registered the global and regional trends of AUD, ALD, and alcohol-related liver cancer using data from the Global Burden of Disease 2021 Study, the largest and most up-to-date global epidemiology database. We estimated the annual percent change (APC) and its 95% confidence interval (CI) to assess changes in age-standardized rates over time. Results In 2021, there were 111.12 million cases of AUD, 3.02 million cases of ALD, and 132,030 cases of alcohol-attributable primary liver cancer. Between 2000 and 2021, there was a 14.66% increase in AUD, a 38.68% increase in ALD, and a 94.12% increase in alcohol-attributable primary liver cancer prevalence. While the age-standardized prevalence rate for liver cancer from alcohol increased (APC 0.59%; 95% confidence interval [CI] 0.52 to 0.67%) over these years, it decreased for ALD (APC –0.71%; 95% CI –0.75 to –0.67%) and AUD (APC –0.90%; 95% CI –0.94 to –0.86%). There was significant variation by region, socioeconomic development level, and sex. During the last years (2019–2021), the prevalence, incidence, and death of ALD increased to a greater extent in females. Conclusions Given the high burden of AUD, ALD, and alcohol-attributable primary liver cancer, urgent measures are needed to prevent them at both global and national levels.
dc.fuente.origenORCID
dc.identifier.doi10.3350/cmh.2024.0835
dc.identifier.issn2287-2728
dc.identifier.urihttps://doi.org/10.3350/cmh.2024.0835
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103465
dc.information.autorucEscuela de Medicina; Diaz Piga Luis Antonio; 0000-0002-8540-4930; 179253
dc.information.autorucEscuela de Medicina; Arab Verdugo Juan Pablo; 0000-0002-8561-396X; 132745
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaClinical and Molecular Hepatology
dc.rightsacceso abierto
dc.rights.licenseAtribución-NoComercial 3.0 No portada
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/deed.es
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGlobal epidemiology of alcohol-related liver disease, liver cancer, and alcohol use disorder, 2000–2021
dc.typeartículo
dc.volumen31
sipa.codpersvinculados179253
sipa.codpersvinculados132745
sipa.trazabilidadORCID;2025-04-21
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