Effect of a single dose of pamidronate administered at the time of surgery in a rabbit posterolateral spinal fusion model

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dc.contributor.authorUrrutia, Julio
dc.contributor.authorBriceno, Jorge
dc.contributor.authorCarmona, Maximiliano
dc.contributor.authorOlavarria, Fernando
dc.contributor.authorHodgson, Felipe
dc.date.accessioned2025-01-21T00:05:43Z
dc.date.available2025-01-21T00:05:43Z
dc.date.issued2010
dc.description.abstractSpinal fusion is usually performed on patients who receive bisphosphonates (BP); however, limited data on their action on spinal fusion are available. Previous studies in animal models have shown that chronic administrations of BP reduced spinal fusion rates, and only one study has shown that a single dose administration of zolendronic acid increased fusion rate. The objective of the present study was to evaluate if pamidronate (PA), which was previously demonstrated to reduce spinal fusion rate when administered continuously for 8 weeks, would increase the spinal fusion rate if administered in a single dose at the time of surgery in a rabbit model. Thirty-two New Zealand rabbits underwent an L5-L6 posterolateral intertransverse fusion with iliac crest autograft. Animals were randomized to receive either PA 3 mg/kg in a single dose immediately after surgery, or normal saline. Animals were killed 8 weeks after surgery and fusion was determined by manual palpation and radiographic analysis. Fusion healing was obtained in eight rabbits (50%) in the PA group and in four animals (25%) in the control group, p = 0.137. In a rabbit model, a single dose of PA did not decrease lumbar spinal arthrodesis consolidation rates, but it obtained a nonsignificant higher spinal fusion rate.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00586-010-1288-y
dc.identifier.eissn1432-0932
dc.identifier.issn0940-6719
dc.identifier.urihttps://doi.org/10.1007/s00586-010-1288-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95559
dc.identifier.wosidWOS:000278900400010
dc.issue.numero6
dc.language.isoen
dc.pagina.final944
dc.pagina.inicio940
dc.revistaEuropean spine journal
dc.rightsacceso restringido
dc.subjectSpinal fusion
dc.subjectBisphosphonates
dc.subjectAnimal model
dc.subjectNonunion
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleEffect of a single dose of pamidronate administered at the time of surgery in a rabbit posterolateral spinal fusion model
dc.typeartículo
dc.volumen19
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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