Kurtosis and Skewness of Density Histograms on Inspiratory and Expiratory CT Scans in Smokers

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dc.contributor.authorYamashiro, Tsuneo
dc.contributor.authorMatsuoka, Shin
dc.contributor.authorEstepar, Raul San Jose
dc.contributor.authorBartholmai, Brian J.
dc.contributor.authorDiaz, Alejandro
dc.contributor.authorRoss, James C.
dc.contributor.authorMurayama, Sadayuki
dc.contributor.authorSilverman, Edwin K.
dc.contributor.authorHatabu, Hiroto
dc.contributor.authorWashko, George R.
dc.date.accessioned2024-01-10T12:39:58Z
dc.date.available2024-01-10T12:39:58Z
dc.date.issued2011
dc.description.abstractThe aim of this study is to evaluate the relationship between lung function and kurtosis or skewness of lung density histograms on computed tomography (CT) in smokers. Forty-six smokers (age range 46-81 years), enrolled in the Lung Tissue Research Consortium, underwent pulmonary function tests (PFT) and chest CT at full inspiration and full expiration. On both inspiratory and expiratory scans, kurtosis and skewness of the density histograms were automatically measured by open-source software. Correlations between CT measurements and lung function were evaluated by the linear regression analysis. Although no significant correlations were found between inspiratory kurtosis or skewness and PFT results, expiratory kurtosis significantly correlated with the following: the percentage of predicted value of forced expiratory volume in the first second (FEV1), the ratio of FEV1 to forced vital capacity (FVC), and the ratio of residual volume (RV) to total lung capacity (TLC) (FEV1%predicted, R = -0.581, p < 0.001; FEV1/FVC, R = -0.612, p < 0.001; RV/TLC, R = 0.613, p < 0.001, respectively). Similarly, expiratory skewness showed significant correlations with PFT results (FEV1%predicted, R = -0.584, p < 0.001; FEV1/FVC, R = -0.619, p < 0.001; RV/TLC, R = 0.585, p < 0.001, respectively). Also, the expiratory/inspiratory (E/I) ratios of kurtosis and skewness significantly correlated with FEV1%predicted (p < 0.001), FEV1/FVC (p < 0.001), RV/TLC (p < 0.001), and the percentage of predicted value of diffusing capacity for carbon monoxide (kurtosis E/I ratio, p = 0.001; skewness E/I ratio, p = 0.03, respectively). We conclude therefore that expiratory values and the E/I ratios of kurtosis and skewness of CT densitometry reflect airflow limitation and air-trapping. Higher kurtosis or skewness on expiratory CT scan indicates more severe conditions in smokers.
dc.description.funderNIH
dc.description.funderParker B. Francis Foundation
dc.description.funderNational Heart, Lung, and Blood Institute (NHLBI)
dc.description.funderGlaxoSmithKline
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3109/15412555.2010.541537
dc.identifier.eissn1541-2563
dc.identifier.issn1541-2555
dc.identifier.pubmedidMEDLINE:21299474
dc.identifier.urihttps://doi.org/10.3109/15412555.2010.541537
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77255
dc.identifier.wosidWOS:000288620200004
dc.information.autorucMedicina;Diaz A;S/I;104496
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final20
dc.pagina.inicio13
dc.publisherINFORMA HEALTHCARE
dc.revistaCOPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
dc.rightsacceso restringido
dc.subjectChronic obstructive pulmonary disease
dc.subjectComputed tomography
dc.subjectPulmonary emphysema
dc.subjectDensity histogram
dc.subjectAirflow limitation
dc.subjectOBSTRUCTIVE PULMONARY-DISEASE
dc.subjectHIGH-RESOLUTION CT
dc.subjectBONE-MARROW-TRANSPLANTATION
dc.subjectBRONCHIOLITIS OBLITERANS SYNDROME
dc.subjectCOMPUTED-TOMOGRAPHY
dc.subjectQUANTITATIVE ASSESSMENT
dc.subjectTHIN-SECTION
dc.subjectAIRWAY-OBSTRUCTION
dc.subjectSYSTEMIC-SCLEROSIS
dc.subjectFUNCTION TESTS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleKurtosis and Skewness of Density Histograms on Inspiratory and Expiratory CT Scans in Smokers
dc.typeartículo
dc.volumen8
sipa.codpersvinculados104496
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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