Perindopril regulates beta-agonist-induced cardiac apoptosis

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dc.contributor.authorGalvez, AS
dc.contributor.authorFiedler, JL
dc.contributor.authorOcaranza, MP
dc.contributor.authorJalil, JE
dc.contributor.authorLavandero, S
dc.contributor.authorDiaz Araya, G
dc.date.accessioned2024-01-10T13:16:10Z
dc.date.available2024-01-10T13:16:10Z
dc.date.issued2005
dc.description.abstractAdministration of the P-adrenergic agonist isoproterenol results in cardiac apoptosis. The effect of short-term P-adrenergic stimulation by isoproterenol on the activity of plasma, lung, and left ventricular (LV) angiotensin 1-converting enzyme (ACE) activity and its association with the development of cardiac apoptosis was investigated. P-Adrenergic stimulation for 24 hours produced an early increase only in the proapoptotic proteins bax and bcl-XS without changes in the levels of the antiapoptotic protein bcl-XL. The ratio between these bcl family proteins was indicative of apoptosis and correlated with an early and significant increase (300%) in DNA laddering. However, after 5 days of the P-adrenergic stimulation, the ratio changed in favor of antiapoptotic proteins and correlated with the absence of DNA fragmentation. In addition, LV and plasma ACE activities increased markedly with isoproterenol over the study period up to 5 days. ACE activity also regulated expression of the antiapoptotic gene bcl-XL. The administration of perindopril (an ACE inhibitor) prevented the observed increase in bax and bcl-XS levels and attenuated (50% decrease, P < 0.05) the effect of isoproterenol on DNA fragmentation. Thus, early and transient cardiac apoptosis triggered by the beta-adrenergic agonist isoproterenol is reversed in the presence of perindopril.
dc.fechaingreso.objetodigital2024-06-14
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/01.fjc.0000175234.95831.3e
dc.identifier.eissn1533-4023
dc.identifier.issn0160-2446
dc.identifier.pubmedidMEDLINE:16116328
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78564
dc.identifier.wosidWOS:000235093700003
dc.information.autorucMedicina;Jalil J;S/I;99946
dc.information.autorucMedicina;Ocaranza M;S/I;1001254
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final261
dc.pagina.inicio255
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaJOURNAL OF CARDIOVASCULAR PHARMACOLOGY
dc.rightsacceso restringido
dc.subjectapoptosis
dc.subjectACE inhibitor
dc.subjectbeta-adrenergic agonist
dc.subjectheart
dc.subjectANGIOTENSIN-CONVERTING ENZYME
dc.subjectMYOCYTE CELL-DEATH
dc.subjectRECEPTOR BLOCKADE
dc.subjectACE-INHIBITION
dc.subjectIN-VITRO
dc.subjectCARDIOMYOCYTE APOPTOSIS
dc.subjectISCHEMIA-REPERFUSION
dc.subjectVENTRICULAR MYOCYTES
dc.subjectRAT
dc.subjectHYPERTROPHY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePerindopril regulates beta-agonist-induced cardiac apoptosis
dc.typeartículo
dc.volumen46
sipa.codpersvinculados99946
sipa.codpersvinculados1001254
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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