<i>Rickettsia felis</i> DNA recovered from a child who lived in southern Africa 2000 years ago

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dc.contributor.authorRifkin, Riaan F. F.
dc.contributor.authorVikram, Surendra
dc.contributor.authorAlcorta, Jaime
dc.contributor.authorRamond, Jean-Baptiste
dc.contributor.authorCowan, Don A. A.
dc.contributor.authorJakobsson, Mattias
dc.contributor.authorSchlebusch, Carina M. M.
dc.contributor.authorLombard, Marlize
dc.date.accessioned2025-01-20T20:16:47Z
dc.date.available2025-01-20T20:16:47Z
dc.date.issued2023
dc.description.abstractThe Stone Age record of South Africa provides some of the earliest evidence for the biological and cultural origins of Homo sapiens. While there is extensive genomic evidence for the selection of polymorphisms in response to pathogen-pressure in sub-Saharan Africa, e.g., the sickle cell trait which provides protection against malaria, there is inadequate direct human genomic evidence for ancient human-pathogen infection in the region. Here, we analysed shotgun metagenome libraries derived from the sequencing of a Later Stone Age hunter-gatherer child who lived near Ballito Bay, South Africa, c. 2000 years ago. This resulted in the identification of ancient DNA sequence reads homologous to Rickettsia felis, the causative agent of typhus-like flea-borne rickettsioses, and the reconstruction of an ancient R. felis genome.
dc.description.abstractAncient genomic evidence for Rickettsia felis presence in human remains from 2000 years ago reframes previous hypotheses of R. felis as a novel or emergent pathogen in modern humans.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s42003-023-04582-y
dc.identifier.eissn2399-3642
dc.identifier.urihttps://doi.org/10.1038/s42003-023-04582-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92354
dc.identifier.wosidWOS:000943534900002
dc.issue.numero1
dc.language.isoen
dc.revistaCommunications biology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.title<i>Rickettsia felis</i> DNA recovered from a child who lived in southern Africa 2000 years ago
dc.typeartículo
dc.volumen6
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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