Profile of urinary arsenic metabolites during pregnancy

Simple item page
dc.contributor.authorHopenhayn, C
dc.contributor.authorHuang, B
dc.contributor.authorChristian, J
dc.contributor.authorPeralta, C
dc.contributor.authorFerreccio, C
dc.contributor.authorAtallah, R
dc.contributor.authorKalman, D
dc.date.accessioned2024-01-10T13:16:41Z
dc.date.available2024-01-10T13:16:41Z
dc.date.issued2003
dc.description.abstractChronic exposure to inorganic arsenic (In-As) from drinking water is associated with different health effects, including skin, lung, bladder, and kidney cancer as well as vascular and possibly reproductive effects. In-As is metabolized through the process of methylation, resulting in the production and excretion of methylated species, mainly monomethylarsenate (MMA) and dimethylarsenate (DMA). Because a large percentage of the dose is excreted in urine, the distribution of urinary In-As, MMA, and DMA is considered a useful indicator of methylation patterns in human populations. Several factors affect these patterns, including sex and exposure level. In this study, we investigated the profile of urinary in-As, MMA, and DMA of pregnant women. Periodic urine samples were collected from early to late pregnancy among 29 pregnant women living in Antofagasta, Chile, who drank tap water containing 40 mug/L In-As. The total urinary arsenic across four sampling periods increased with increasing weeks of gestation, from an initial mean value of 36.1 to a final value of 54.3 mug/L. This increase was mainly due to an increase in DMA, resulting in lower percentages of In-As and MMA and a higher percentage of DMA. Our findings indicate that among women exposed to moderate arsenic from drinking water during pregnancy, changes occur in the pattern of urinary arsenic excretion and metabolite distribution. The toxicologic significance of this is not dear, given recent evidence suggesting that intermediate methylated species may be highly toxic. Nevertheless, this study suggests that arsenic metabolism changes throughout the course of pregnancy, which in turn may have toxicologic effects on the developing fetus.
dc.fechaingreso.objetodigital2024-05-16
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1289/ehp.6254
dc.identifier.eissn1552-9924
dc.identifier.issn0091-6765
dc.identifier.pubmedidMEDLINE:14644662
dc.identifier.urihttps://doi.org/10.1289/ehp.6254
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78604
dc.identifier.wosidWOS:000187034000034
dc.information.autorucMedicina;Ferreccio F;S/I;99684
dc.issue.numero16
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final1891
dc.pagina.inicio1888
dc.publisherUS DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
dc.revistaENVIRONMENTAL HEALTH PERSPECTIVES
dc.rightsacceso abierto
dc.subjectarsenic
dc.subjectarsenic metabolism
dc.subjectarsenic methylation
dc.subjectChile
dc.subjectpregnancy
dc.subjecturinary arsenic
dc.subjectMETHYLATED ARSENICALS
dc.subjectEXPOSURE
dc.subjectTRIVALENT
dc.subjectEXCRETION
dc.subjectTOXICITY
dc.subjectACID
dc.subject.ods06 Clean Water and Sanitation
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa06 Agua limpia y saneamiento
dc.subject.odspa03 Salud y bienestar
dc.titleProfile of urinary arsenic metabolites during pregnancy
dc.typeartículo
dc.volumen111
sipa.codpersvinculados99684
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Environmental Health Perspectives - 2003 - Profile of Urinary Arsenic Metabolites during Pregnancy.pdf
Size:
110.9 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas