Instruments assessing risk of bias of randomized trials frequently included items that are not addressing risk of bias issues

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dc.contributor.authorWang, Ying
dc.contributor.authorGhadimi, Maryam
dc.contributor.authorWang, Qi
dc.contributor.authorHou, Liangying
dc.contributor.authorZeraatkar, Dena
dc.contributor.authorIqbal, Atiya
dc.contributor.authorHo, Cameron
dc.contributor.authorYao, Liang
dc.contributor.authorHu, Malini
dc.contributor.authorYe, Zhikang
dc.contributor.authorCouban, Rachel
dc.contributor.authorArmijo-Olivo, Susan
dc.contributor.authorBassler, Dirk
dc.contributor.authorBriel, Matthias
dc.contributor.authorGluud, Lise Lotte
dc.contributor.authorGlasziou, Paul
dc.contributor.authorJackson, Rod
dc.contributor.authorKeitz, Sheri A.
dc.contributor.authorLetelier, Luz M.
dc.contributor.authorRavaud, Philippe
dc.contributor.authorSchulz, Kenneth F.
dc.contributor.authorSiemieniuk, Reed A. C.
dc.contributor.authorBrignardello-Petersen, Romina
dc.contributor.authorGuyatt, Gordon H.
dc.date.accessioned2025-01-20T21:00:57Z
dc.date.available2025-01-20T21:00:57Z
dc.date.issued2022
dc.description.abstractObjectives: To establish whether items included in instruments published in the last decade assessing risk of bias of randomized controlled trials (RCTs) are indeed addressing risk of bias.Study Design and Setting: We searched Medline, Embase, Web of Science, and Scopus from 2010 to October 2021 for instruments assessing risk of bias of RCTs. By extracting items and summarizing their essential content, we generated an item list. Items that two re-viewers agreed clearly did not address risk of bias were excluded. We included the remaining items in a survey in which 13 experts judged the issue each item is addressing: risk of bias, applicability, random error, reporting quality, or none of the above.Results: Seventeen eligible instruments included 127 unique items. After excluding 61 items deemed as clearly not addressing risk of bias, the item classification survey included 66 items, of which the majority of respondents deemed 20 items (30.3%) as addressing risk of bias; the majority deemed 11 (16.7%) as not addressing risk of bias; and there proved substantial disagreement for 35 (53.0%) items. Conclusion: Existing risk of bias instruments frequently include items that do not address risk of bias. For many items, experts disagree on whether or not they are addressing risk of bias.(c) 2022 Elsevier Inc. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jclinepi.2022.10.018
dc.identifier.eissn1878-5921
dc.identifier.issn0895-4356
dc.identifier.urihttps://doi.org/10.1016/j.jclinepi.2022.10.018
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92786
dc.identifier.wosidWOS:000905334600011
dc.language.isoen
dc.pagina.final225
dc.pagina.inicio218
dc.revistaJournal of clinical epidemiology
dc.rightsacceso restringido
dc.subjectRisk of bias
dc.subjectMethodological quality
dc.subjectInstrument
dc.subjectRandomized controlled trials
dc.subjectSystematic reviews
dc.subjectSystematic survey
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInstruments assessing risk of bias of randomized trials frequently included items that are not addressing risk of bias issues
dc.typeartículo
dc.volumen152
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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