Novel Schiff base iron(ii) phthalocyanine with composite MWCNTs on modified GCE: electrochemical sensor development for paracetamol

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dc.contributor.authorMounesh
dc.contributor.authorReddy, K. R. Venugopala
dc.contributor.authorYuvaraja, D.
dc.contributor.authorManriquez, Juan M.
dc.contributor.authorLokesh, K. S.
dc.contributor.authorAmshumali, M. K.
dc.date.accessioned2025-01-20T21:02:52Z
dc.date.available2025-01-20T21:02:52Z
dc.date.issued2022
dc.description.abstractThe synthesis and characterization of novel peripherally tetra-substituted Schiff base iron(ii) phthalocyanines (iron(ii) (2Z)-2-(3-chlorobenzylidene)hydrazinecarbothiocarboxamide phthalocyanine (FeTClBCTCAPc)) are described for the first time in this study. The Schiff base ligand and FeTClBCTCAPc complex are characterized by a combination of IR, H-1 NMR, mass spectroscopy, XRD, TGA and UV-vis spectroscopy techniques. The stepwise fabrication process of the FeTClBCTCAPc@GC electrode with composite MWCNTs and its electrochemical sensing performance towards paracetamol (PA) was evaluated using cyclic voltammetry (CV), linear sweep voltammetry (LSV), chronoamperometry (CA) and differential pulse voltammetry (DPV). Compared with the MWCNT-modified electrode, the FeTClBCTCAPc@MWCNTs/GC electrode shows a better electrocatalytic activity for the oxidation of PA with lower oxidation potential and larger peak current, so the FeTClBCTCAPc@MWCNTs/GC electrode nanocomposite can be used as an enhanced sensing platform for the electrochemical determination of PA. The kinetic parameters of PA electro-oxidation at FeTClBCTCAPc@MWCNTs/GC electrodes were studied in detail, and the determination conditions were optimized. Under the optimal conditions, the oxidation peak current is linear to the PA concentration in the range (detection limit) 50-900 nM (18.5 nM) for CA, 50-500 nM (20.5 nM) for CV, 50-500 nM (15 nM) for DPV, and 50-500 nM (15.5 nM) for LSV. Based on the high sensitivity, stability and good selectivity of the FeTClBCTCAPc@MWCNTs/GC electrode, the proposed method was successfully applied to the determination of PA in commercial tablet samples, and the satisfactory results confirm the applicability of this sensor in practical analysis.
dc.description.funderVijayanagara Srikrishnadevaraya University SC/ST fellowship
dc.fuente.origenWOS
dc.identifier.doi10.1039/d2re00193d
dc.identifier.issn2058-9883
dc.identifier.urihttps://doi.org/10.1039/d2re00193d
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93094
dc.identifier.wosidWOS:000848865300001
dc.issue.numero12
dc.language.isoen
dc.pagina.final2561
dc.pagina.inicio2550
dc.revistaReaction chemistry & engineering
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNovel Schiff base iron(ii) phthalocyanine with composite MWCNTs on modified GCE: electrochemical sensor development for paracetamol
dc.typeartículo
dc.volumen7
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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