Geographic variation of gallbladder cancer mortality and risk factors in Chile: A population-based ecologic study

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dc.contributor.authorAndia, Marcelo E.
dc.contributor.authorHsing, Ann W.
dc.contributor.authorAndreotti, Gabriella
dc.contributor.authorFerreccio, Catterina
dc.date.accessioned2024-01-10T12:05:42Z
dc.date.available2024-01-10T12:05:42Z
dc.date.issued2008
dc.description.abstractChile's gallbladder cancer rates are among the highest in the world, being the leading cause of cancer deaths among Chilean women. To provide insights into the etiology of gallbladder cancer, we conducted an ecologic study examining the geographical variation of gallbladder cancer and several putative risk factors. The relative risk of dying from gallbladder cancer between 1985 and 2003 was estimated for each of the 333 Chilean counties, using a hierarchical Poisson regression model, adjusting for age, sex and geographical location. The risk of gallbladder cancer mortality was analyzed in relation to region, poverty, Amerindian (Mapuche) population, typhoid fever and access to cholecystectomy, using logistic regression analysis. There were 27,183 gallbladder cancer deaths, with age and sex-adjusted county mortality rates ranging from 8.2 to 12.4 per 100,000 inhabitants. Rates were highest in inland and southern regions. Compared to the northern-coast, the northern-inland region had a 10-fold risk (95% of confidence interval (95% CI): 2.4-42.2) and the southern-inland region had a 26-fold risk (95% CI: 6.0-114.2). Independent of region, other risk factors for gallbladder cancer included a high Mapuche population (Odds ratio (011):3.9, 95% CI 1.8-8.7), high typhoid fever incidence (011:2.9, 95% Cl 1.2-6.9), high poverty (011:5.1., 95% CI 1.6-15.9), low access to cholecystectomy (011:3.9, 95% CI 1.5-10.1), low access to hospital care (011:14.2, 95% C1 4.2-48.7) and high urbanization (011:8.0, 95% CI 3.4-18.7). Our results suggest that gallbladder cancer in Chile may be related to both genetic factors and poor living conditions. Future analytic studies are needed to further clarify the role of these factors in gallbladder cancer etiology. Published 2008 Wiley-Liss, Inc.
dc.description.funderIntramural NIH HHS
dc.fechaingreso.objetodigital05-04-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/ijc.23662
dc.identifier.eissn1097-0215
dc.identifier.issn0020-7136
dc.identifier.pubmedidMEDLINE:18566990
dc.identifier.urihttps://doi.org/10.1002/ijc.23662
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76055
dc.identifier.wosidWOS:000258480100025
dc.information.autorucMedicina;Andia M;S/I;90691
dc.information.autorucMedicina;Ferreccio C;S/I;99684
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1416
dc.pagina.inicio1411
dc.publisherWILEY
dc.revistaINTERNATIONAL JOURNAL OF CANCER
dc.rightsacceso restringido
dc.subjectgallbladder cancer
dc.subjectgallstones
dc.subjectMapuche
dc.subjecttyphoid
dc.subjectgenetics
dc.subjectBILIARY-TRACT CANCER
dc.subjectK-RAS
dc.subjectMICROSATELLITE INSTABILITY
dc.subjectABORIGINAL POPULATIONS
dc.subjectSALMONELLA-TYPHI
dc.subjectGALLSTONES
dc.subjectCHINA
dc.subjectEPIDEMIOLOGY
dc.subjectSHANGHAI
dc.subjectCARCINOMA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGeographic variation of gallbladder cancer mortality and risk factors in Chile: A population-based ecologic study
dc.typeartículo
dc.volumen123
sipa.codpersvinculados90691
sipa.codpersvinculados99684
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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