Fractional Anisotropy changes in Parahippocampal Cingulum due to Alzheimer's Disease

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dc.contributor.authorda Rocha, Josue Luiz Dalboni
dc.contributor.authorBramati, Ivanei
dc.contributor.authorCoutinho, Gabriel
dc.contributor.authorMoll, Fernanda Tovar
dc.contributor.authorSitaram, Ranganatha
dc.date.accessioned2025-01-23T19:49:00Z
dc.date.available2025-01-23T19:49:00Z
dc.date.issued2020
dc.description.abstractCurrent treatments for Alzheimer's disease are only symptomatic and limited to reduce the progression rate of the mental deterioration. Mild Cognitive Impairment, a transitional stage in which the patient is not cognitively normal but do not meet the criteria for specific dementia, is associated with high risk for development of Alzheimer's disease. Thus, non-invasive techniques to predict the individual's risk to develop Alzheimer's disease can be very helpful, considering the possibility of early treatment. Diffusion Tensor Imaging, as an indicator of cerebral white matter integrity, may detect and track earlier evidence of white matter abnormalities in patients developing Alzheimer's disease. Here we performed a voxel-based analysis of fractional anisotropy in three classes of subjects: Alzheimer's disease patients, Mild Cognitive Impairment patients, and healthy controls. We performed Support Vector Machine classification between the three groups, using Fisher Score feature selection and Leave-one-out cross-validation. Bilateral intersection of hippocampal cingulum and parahippocampal gyrus (referred as parahippocampal cingulum) is the region that best discriminates Alzheimer's disease fractional anisotropy values, resulting in an accuracy of 93% for discriminating between Alzheimer's disease and controls, and 90% between Alzheimer's disease and Mild Cognitive Impairment. These results suggest that pattern classification of Diffusion Tensor Imaging can help diagnosis of Alzheimer's disease, specially when focusing on the parahippocampal cingulum.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-020-59327-2
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-020-59327-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100473
dc.identifier.wosidWOS:000562932300020
dc.issue.numero1
dc.language.isoen
dc.revistaScientific reports
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFractional Anisotropy changes in Parahippocampal Cingulum due to Alzheimer's Disease
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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