Statistical explanation of the protective effect of four COVID-19 vaccine doses in the general population

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dc.contributor.authorReyes, Humberto
dc.contributor.authorMendez, Constanza
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2025-01-20T17:32:13Z
dc.date.available2025-01-20T17:32:13Z
dc.date.issued2023
dc.description.abstractObjectives: To assess the effectiveness of four doses of the vaccine against SARS-CoV-2 in the general population and the impact of this on the severity of the disease by age group. Methods: By using data from the health authority public data base, we build statistical models using R and the GAMLSS library to explain the behavior of new SARS-CoV-2 infections, active COVID-19 cases, ICU bed requirement total and by age group, and deaths at the national level. Results: The four doses of vaccine and at least the interaction between the first and second doses were important explanatory factors for the protective effect against COVID-19. The R-2 for new cases per day was 0.5644 and for occupied ICU beds the R-2 is 0.9487. For occupied ICU beds for >70 years R-2 is 0.9195 and with the interaction between 4 doses as the main factor. Conclusions: Although the increase in the number of vaccine doses did not adequately explain the decrease in the number of COVID-19 cases, it explained the decrease in ICU admissions and deaths nationwide and by age group.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fpubh.2023.1253762
dc.identifier.eissn2296-2565
dc.identifier.urihttps://doi.org/10.3389/fpubh.2023.1253762
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91622
dc.identifier.wosidWOS:001081629000001
dc.language.isoen
dc.revistaFrontiers in public health
dc.rightsacceso restringido
dc.subjectCOVID-19
dc.subjectvaccination
dc.subjectICU hospitalizations
dc.subjectexplanatory model
dc.subjectGAMLSS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStatistical explanation of the protective effect of four COVID-19 vaccine doses in the general population
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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