Impact of Public Health Policies on Alcohol-Associated Liver Disease in Latin America: An Ecological Multinational Study

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dc.catalogadorvzp
dc.contributor.authorDiaz Piga, Luis Antonio
dc.contributor.authorIdalsoaga Ferrer, Francisco Javier
dc.contributor.authorFuentes López, Eduardo
dc.contributor.authorMarquez Lomas, Andrea
dc.contributor.authorRamirez, Carolina A.
dc.contributor.authorPablo Roblero, Juan
dc.contributor.authorAraujo, Roberta C.
dc.contributor.authorHiguera de la Tijera, Fatima
dc.contributor.authorGuillermo Toro, Luis
dc.contributor.authorPazmino, Galo
dc.contributor.authorMontes, Pedro
dc.contributor.authorHernandez, Nelia
dc.contributor.authorMendizabal, Manuel
dc.contributor.authorCorsi, Oscar
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorLazo, Mariana
dc.contributor.authorBrahmania, Mayur
dc.contributor.authorSingal, Ashwani K.
dc.contributor.authorBataller, Ramon
dc.contributor.authorArrese Jimenez, Marco Antonio
dc.contributor.authorArab Verdugo, Juan Pablo
dc.date.accessioned2024-01-29T17:33:10Z
dc.date.available2024-01-29T17:33:10Z
dc.date.issued2021
dc.description.abstractBackground and Aims Alcohol-associated liver disease (ALD) is the leading cause of liver-related mortality in Latin America, yet the impact of public health policies (PHP) on liver disease is unknown. We aimed to assess the association between alcohol PHP and deaths due to ALD in Latin American countries. Approach and Results We performed an ecological multinational study including 20 countries in Latin America (628,466,088 inhabitants). We obtained country-level sociodemographic information from the World Bank Open Data source. Alcohol-related PHP data for countries were obtained from the World Health Organization Global Information System of Alcohol and Health. We constructed generalized linear models to assess the association between the number of PHP (in 2010) and health outcomes (in 2016). In Latin America, the prevalence of obesity was 27% and 26.1% among male and female populations, respectively. The estimated alcohol per capita consumption among the population at 15 years old or older was 6.8 L of pure alcohol (5.6 recorded and 1.2 unrecorded). The overall prevalence of alcohol use disorders (AUD) was 4.9%. ALD was the main cause of cirrhosis in 64.7% of male and 40.0% of female populations. A total of 19 (95%) countries have at least one alcohol-related PHP on alcohol. The most frequent PHP were limiting drinking age (95%), tax regulations (90%), drunk-driving policies and countermeasures (90%), and government monitoring systems and community support (90%). A higher number of PHP was associated with a lower ALD mortality (PR, 0.76; 95% CI, 0.61-0.93; P = 0.009), lower AUD prevalence (PR, 0.80; 95% CI, 0.65-0.99; P = 0.045), and lower alcohol-attributable road traffic deaths (PR, 0.81; 95% CI, 0.65-1.00; P = 0.051). Conclusions Our study indicates that in Latin America, countries with higher number of PHP have lower mortality due to ALD, lower prevalence of AUD, and lower alcohol-attributable road traffic mortality.
dc.description.funderChilean government through the Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
dc.description.funderComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
dc.description.funderCARE Chile UC
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/hep.32016
dc.identifier.eissn1527-3350
dc.identifier.issn0270-9139
dc.identifier.pubmedidMEDLINE:34134172
dc.identifier.urihttps://doi.org/10.1002/hep.32016
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81010
dc.identifier.wosidWOS:000687031800001
dc.information.autorucEscuela de Medicina; Diaz Piga Luis Antonio; S/I; 179253
dc.information.autorucEscuela de Medicina; Idalsoaga Ferrer Francisco Javier; S/I; 1017394
dc.information.autorucEscuela de Medicina; Fuentes Lopez Eduardo; 0000-0002-0141-0226; 1013849
dc.information.autorucEscuela de Medicina; Arrese Jimenez Marco Antonio; 0000-0002-0499-4191; 76095
dc.information.autorucEscuela de Medicina; Arab Verdugo Juan Pablo; 0000-0002-8561-396X; 132745
dc.issue.numero5
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final2490
dc.pagina.inicio2478
dc.publisherWILEY
dc.revistaHepatology
dc.rightsacceso restringido
dc.subjectAttributable mortality
dc.subjectAge
dc.subjectAbstinence
dc.subjectDrinking
dc.subjectBurden
dc.subject.ddc610
dc.subject.deweyMedicina y salud
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImpact of Public Health Policies on Alcohol-Associated Liver Disease in Latin America: An Ecological Multinational Study
dc.typeartículo
dc.volumen74
sipa.codpersvinculados179253
sipa.codpersvinculados1017394
sipa.codpersvinculados1013849
sipa.codpersvinculados76095
sipa.codpersvinculados132745
sipa.trazabilidadWOS;18-03-2022
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