A PREPUBERTAL SURGE OF THYROTROPIN PRECEDES AN INCREASE IN THYROXINE AND 3,5,3'-TRIIODOTHYRONINE IN NORMAL-CHILDREN

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dc.contributor.authorMICHAUD, P
dc.contributor.authorFORADORI, A
dc.contributor.authorRODRIGUEZPORTALES, JA
dc.contributor.authorARTEAGA, E
dc.contributor.authorLOPEZ, JM
dc.contributor.authorTELLEZ, R
dc.date.accessioned2024-01-10T13:11:12Z
dc.date.available2024-01-10T13:11:12Z
dc.date.issued1991
dc.description.abstractThe variations in plasma levels of TSH, T4, T3, and rT3, during the pubertal period, were studied in 647 school students from the urban area of Santiago in Chile (47% males and 53% females) with ages ranging between 7.5 and 15 yr. The subjects were grouped by age in consecutive intervals of 6 months each, and pubertal development was determined in every subject. TSH showed a significant increase, reaching a peak in the 9- to 9.5-yr interval. The same was found for T3 and T4, which reached a peak by 10 and 11 yr. The T4/T3 ratio did not show any significant variation with age. After 9.5 yr, a decrease in rT3 and increase in the T4/rT3 ratio was found. The TSH peak preceded the onset of clinical pubertal development, while the T3 and T4 peaks coincided with this onset. The variations in rT3 suggest an increase of peripheral conversion of T4 to T3. These transient events, not described until now, could be termed thyroidarche and could have a significant effect on pubertal growth and development.
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1210/jcem-72-5-976
dc.identifier.issn0021-972X
dc.identifier.pubmedidMEDLINE:2022717
dc.identifier.urihttps://doi.org/10.1210/jcem-72-5-976
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78013
dc.identifier.wosidWOS:A1991FH99600005
dc.information.autorucMedicina;Arteaga Urzua Eugenio;S/I;98586
dc.information.autorucMedicina;Lopez J;S/I;98466
dc.information.autorucMedicina;Michaud P;S/I;98221
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final981
dc.pagina.inicio976
dc.publisherENDOCRINE SOC
dc.revistaJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
dc.rightsacceso restringido
dc.subjectREVERSE T3
dc.subjectSERUM
dc.subjectADOLESCENTS
dc.subjectHORMONE
dc.subjectTSH
dc.subjectAGE
dc.subjectT4
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleA PREPUBERTAL SURGE OF THYROTROPIN PRECEDES AN INCREASE IN THYROXINE AND 3,5,3'-TRIIODOTHYRONINE IN NORMAL-CHILDREN
dc.typeartículo
dc.volumen72
sipa.codpersvinculados98586
sipa.codpersvinculados98466
sipa.codpersvinculados98221
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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