Low-Grade Chronic Inflammation: a Shared Mechanism for Chronic Diseases

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dc.catalogadorjlo
dc.contributor.authorCifuentes, Mariana
dc.contributor.authorVerdejo Pinochet, Hugo Eduardo
dc.contributor.authorCastro Gálvez, Pablo Federico
dc.contributor.authorCorvalán Rodríguez, Alejandro
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorQuest, Andrew F. G.
dc.contributor.authorKogan, Marcelo J.
dc.contributor.authorLavandero, Sergio
dc.date.accessioned2025-03-17T14:57:25Z
dc.date.available2025-03-17T14:57:25Z
dc.date.issued2025
dc.description.abstractInflammation is an important physiological response of the organism to restore homeostasis upon pathogenic or damaging stimuli. However, the persistence of the harmful trigger or a deficient resolution of the process can evolve into a state of low-grade, chronic inflammation. This condition is strongly associated with the development of several increasingly prevalent and serious chronic conditions, such as obesity, cancer, and cardiovascular diseases, elevating overall morbidity and mortality worldwide. The current pandemic of chronic diseases underscores the need to address chronic inflammation, its pathogenic mechanisms, and potential preventive measures to limit its current widespread impact. The present review discusses the current knowledge and research gaps regarding the association between low-grade chronic inflammation and chronic diseases, focusing on obesity, cardiovascular diseases, digestive diseases, and cancer. We examine the state of the art in selected aspects of the topic and propose future directions and approaches for the field.
dc.format.extent22 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.1152/physiol.00021.2024
dc.identifier.issn1548-9221
dc.identifier.scopusidSCOPUS_ID:85209598305
dc.identifier.urihttps://doi.org/10.1152/physiol.00021.2024
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102668
dc.information.autorucEscuela de Medicina; Verdejo Pinochet, Hugo Eduardo; 0000-0003-0078-4792; 1001175
dc.information.autorucEscuela de Medicina; Castro Gálvez, Pablo Federico; S/I; 100212
dc.information.autorucEscuela de Medicina; Corvalán Rodríguez, Alejandro; 0000-0001-5492-3853; 63885
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final25
dc.pagina.inicio4
dc.revistaPhysiology
dc.rightsacceso restringido
dc.subjectCancer
dc.subjectCardiovascular disease
dc.subjectChronic disease
dc.subjectInflammation
dc.subjectObesity
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleLow-Grade Chronic Inflammation: a Shared Mechanism for Chronic Diseases
dc.typeartículo
dc.volumen40
sipa.codpersvinculados1001175
sipa.codpersvinculados100212
sipa.codpersvinculados63885
sipa.trazabilidadSCOPUS;2024-12-08
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