Neutrophil/lymphocyte ratio in complete blood count as a mortality predictor in breast cancer

Simple item page
dc.contributor.authorMimica, Ximena
dc.contributor.authorAcevedo, Francisco
dc.contributor.authorOddo, David
dc.contributor.authorIbanez, Carolina
dc.contributor.authorMedina, Lidia
dc.contributor.authorKalergis, Alexis
dc.contributor.authorCamus, Mauricio
dc.contributor.authorSanchez, Cesar
dc.date.accessioned2024-01-10T13:51:05Z
dc.date.available2024-01-10T13:51:05Z
dc.date.issued2016
dc.description.abstractBackground: The white blood cell count is one of the most sensitive markers associated with inflammation. The neutrophil/lymphocyte count ratio may be an independent factor for breast cancer mortality. Aim: To assess the predictive value of the neutrophil/lymphocyte ratio for mortality in breast cancer. Material and Methods: Review of the database of a cancer center of a University hospital. Patients with infiltrating breast cancer treated between 1997 and 2012 were selected. The pathology type and lymph node involvement were obtained from the pathology report. The expression of estrogen, progesterone and Human Epidermal Growth Factor Receptor 2 (HER2) was determined by immunohistochemistry or in situ fluorescent hybridization (FISH). The absolute peripheral neutrophil and lymphocyte counts were obtained from a complete blood count obtained at least three months before treatment. Patients were followed for a median of 61 months (range 1-171). Results: From 323 eligible patients, after excluding those in stage IV and those without an available complete blood count, 131 patients were analyzed (81 with negative receptors and 117 HER2 enriched). The neutrophil/lymphocyte ratio was similar in both types of tumors (2.1 and 1.91 respectively). Twenty two patients died during follow-up. Surviving patients with HER2 enriched tumors had a lower neutrophil/lymphocyte ratio than those who died (1.79 and 3.21 respectively, p < 0.01). In a multivariate analysis, including age, tumor stage and lymph node involvement as confounding factors, the neutrophil/lymphocyte ratio was still significantly associated with a risk of death with a hazard ratio of 2.56. Conclusions: A high neutrophil/lymphocyte ratio in the complete blood count can be a predictor of death in breast cancer.
dc.fechaingreso.objetodigital2024-06-14
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0034-98872016000600001
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:27598486
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79576
dc.identifier.wosidWOS:000380293800001
dc.information.autorucMedicina;Acevedo F;S/I;119540
dc.information.autorucMedicina;Camus M;S/I;100235
dc.information.autorucMedicina;Ibanez C;S/I;146063
dc.information.autorucCiencias Biológicas;Kalergis A;S/I;90610
dc.information.autorucMedicina;Medina L;S/I;18566
dc.information.autorucMedicina;Mimica X;S/I;252742
dc.information.autorucMedicina;Oddo D;S/I;125769
dc.information.autorucMedicina;Sanchez C;S/I;135644
dc.issue.numero6
dc.language.isoes
dc.nota.accesocontenido parcial
dc.pagina.final696
dc.pagina.inicio691
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsacceso restringido
dc.subjectBreast Neoplasms
dc.subjectInflammation
dc.subjectPrognosis
dc.subjectINFLAMMATION
dc.subjectSURVIVAL
dc.subjectTUMOR
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNeutrophil/lymphocyte ratio in complete blood count as a mortality predictor in breast cancer
dc.typeartículo
dc.volumen144
sipa.codpersvinculados119540
sipa.codpersvinculados100235
sipa.codpersvinculados146063
sipa.codpersvinculados90610
sipa.codpersvinculados18566
sipa.codpersvinculados252742
sipa.codpersvinculados125769
sipa.codpersvinculados135644
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Neutrophil-lymphocyte ratio in complete blood count as a mortality predictor in breast cancer.pdf
Size:
3.2 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas