Reversible nitrous oxide myelopathy and a polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase

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dc.contributor.authorLacassie, HJ
dc.contributor.authorNazar, C
dc.contributor.authorYonish, B
dc.contributor.authorSandoval, P
dc.contributor.authorMuir, HA
dc.contributor.authorMellado, P
dc.date.accessioned2025-01-21T01:06:23Z
dc.date.available2025-01-21T01:06:23Z
dc.date.issued2006
dc.description.abstractWe present a case of a patient who received nitrous oxide on two occasions within a period of 8 weeks and who subsequently developed a diffuse myelopathy, characterized by upper extremity paresis, lower extremity paraplegia and neurogenic bladder. Laboratory testing revealed hyper-homocysteinaemia and low levels of vitamin B-12. Because of this uncommon clinical presentation, we analysed the patient's DNA, and found a polymorphism in the MTHFR gene that is associated with the thermolabile isoform of the 5,10-methylenetetrahydrofolate reductase enzyme, which explained the myelopathy experienced by the patient after being exposed to nitrous oxide. Soon after initiating supplementary therapy with folic acid and vitamin B12, the neurological symptoms subsided.
dc.fuente.origenWOS
dc.identifier.doi10.1093/bja/aei300
dc.identifier.issn0007-0912
dc.identifier.urihttps://doi.org/10.1093/bja/aei300
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96147
dc.identifier.wosidWOS:000235306600013
dc.issue.numero2
dc.language.isoen
dc.pagina.final225
dc.pagina.inicio222
dc.revistaBritish journal of anaesthesia
dc.rightsacceso restringido
dc.subjectanaesthesia, inhalation
dc.subjectanaesthetics gases, nitrous oxide
dc.subjectcomplications, myelopathy
dc.subjectenzymes, 5,10-methylenetetrahydrofolate reductase
dc.subjectgene, MTHFR
dc.subjectvitamins, folic acid
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleReversible nitrous oxide myelopathy and a polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase
dc.typeartículo
dc.volumen96
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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