Statin use is not associated with inflammation among Chilean women of Mapuche and non-Mapuche ancestry with gallstones

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dc.contributor.authorJackson, Sarah S.
dc.contributor.authorLex, Marina
dc.contributor.authorVan De Wyngard, Vanessa
dc.contributor.authorCook, Paz
dc.contributor.authorHildesheim, Allan
dc.contributor.authorPinto, Ligia A.
dc.contributor.authorJackson, Sharon H.
dc.contributor.authorChoi, Kelvin
dc.contributor.authorMinas, Tsion Zewdu
dc.contributor.authorMorales, Hector Fabio Losada
dc.contributor.authorAraya, Juan Carlos
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorKoshiol, Jill
dc.contributor.authorPfeiffer, Ruth M.
dc.date.accessioned2025-01-20T17:10:15Z
dc.date.available2025-01-20T17:10:15Z
dc.date.issued2024
dc.description.abstractAim: Statins are associated with lower risk of gallstones due to anti-inflammatory effects. We assessed whether statins impact circulating inflammation among Chilean women with gallstones. Materials & methods: 200 Mapuche women were matched on statin use and age to 200 non-Mapuche women in the Chile Biliary Longitudinal Study. We analyzed 92 inflammatory biomarkers using multivariable-adjusted regression models, random forests and pathway analyses. Results: Statins were not significantly associated with any inflammation marker when women were analyzed jointly or stratified by ancestry. No significant associations were found through random forest methods and pathway analyses. Discussion: We did not find significant associations between statin use and inflammation markers in women with gallstones, suggesting that statins do not reduce inflammation once gallstones have formed.
dc.description.abstractStatins are prescribed to lower cholesterol and can also decrease the risk of gallstone formation by reducing inflammation. We assessed whether statin use reduces inflammation among women who have already developed gallstones. We analyzed 92 inflammation markers among 400 women in Chile, including 200 women with Mapuche Amerindian ancestry and 200 women of Latina/European ancestry. We found that statin use was not correlated with inflammation in this group of women overall nor by ancestry. This may mean that statin use does not reduce inflammation in women who already were diagnosed with gallstones.
dc.fuente.origenWOS
dc.identifier.doi10.2144/fsoa-2023-0032
dc.identifier.issn2056-5623
dc.identifier.urihttps://doi.org/10.2144/fsoa-2023-0032
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91094
dc.identifier.wosidWOS:001139897600002
dc.issue.numero1
dc.language.isoen
dc.revistaFuture science oa
dc.rightsacceso restringido
dc.subjectChile
dc.subjectgallstones
dc.subjectinflammation
dc.subjectMapuche
dc.subjectstatins
dc.subjectwomen
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStatin use is not associated with inflammation among Chilean women of Mapuche and non-Mapuche ancestry with gallstones
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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