Prevalence of Fatty Pancreas and its relation with anthropometric values on the Growth and Obesity Cohort Study

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dc.catalogadorjwg
dc.contributor.authorAlberti Reus, Gigliola Loredana
dc.contributor.authorCantillo Rocha, Thelma De Jesús
dc.contributor.authorPereira, Ana
dc.contributor.authorDe Barbieri Magnone, Florencia Beatriz
dc.contributor.authorGarcia Bruce, Cristian Jorge
dc.contributor.authorDinamarca Villarroel, Luis Antonio
dc.contributor.authorGana Ansaldo, Juan Cristobal
dc.date.accessioned2025-03-18T15:10:13Z
dc.date.available2025-03-18T15:10:13Z
dc.date.issued2024
dc.description.abstractObjective: Nonalcoholic Fatty Pancreas Disease (NAFPD) is characterized by excessive lipid accumulation within the pancreas in the absence of alcohol intake, potentially leading to pancreatic dysfunction and metabolic complications, including type 2 diabetes mellitus, acute and chronic pancreatitis, and pancreatic carcinoma. The authors aim to estimate the prevalence of NAFPD and its association with anthropometric parameters in a cohort of Chilean adolescents. Method: The authors conducted a cross-sectional analysis of the "Growth and Obesity Chilean Cohort Study" (GOCS), a longitudinal study involving nearly 1000 children, followed yearly since 2006. All participants underwent anthropometric measurements and abdominal ultrasonography. Results: A total of 741 adolescents were included; 30 exhibited ultrasonography findings compatible with fatty pancreas (4 %). Adolescents with NAFPD had higher BMI z-score (2.33 (1.52–2.69) vs 0.67 (-0.2–1.4), p < 0.001), waist circumference (WC) (90.9 (81.53–98.58) vs 72.2 (67.55–79.83), p < 0.001), waist-to-height ratio (0.55 (0.48–0.6) vs 0.44 (0.41–0.49), p < 0.001), triponderal index (17.35 (15.14–19.25) vs 13.62 (12.07–15.54), p < 0.001), subcutaneous fat (32.4 (21.77–44.95) vs 16.2 (9.3 - 25.3), p < 0.001), visceral fat (45.15 (36.92–62.08) vs 35.5 (28.55–44.25), p < 0.001), systolic blood pressure (p = 0.009), and diastolic blood pressure but only in boys (p = 0.004) compared with controls. The prevalence of liver steatosis was significantly higher in the NAFPD group (63.3% vs 5.2 %, p < 0.001). After adjusting for sex and BMI, only the association with waist circumference and liver steatosis remains statistically significant. Conclusion: In adolescents, NAFPD has a prevalence of 4 % and is associated with a higher BMI z-score, WC, superficial fat, and blood pressure levels. Liver steatosis exhibited a strong association with NAFPD.
dc.description.funderFondo Nacional de Desarrollo Científico y Tecnológico
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.jped.2024.09.007
dc.identifier.issn16784782 00217557
dc.identifier.scopusidSCOPUS_ID:85212619608
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102731
dc.information.autorucEscuela de Medicina; Alberti Reus, Gigliola Loredana; 0000-0002-8540-1326; 167316
dc.information.autorucEscuela de Medicina; Cantillo Rocha, Thelma De Jesús; S/I; 1080009
dc.information.autorucEscuela de Medicina; De Barbieri Magnone, Florencia Beatriz; S/I; 159736
dc.information.autorucEscuela de Medicina; Garcia Bruce, Cristian Jorge; S/I; 99686
dc.information.autorucEscuela de Medicina; Dinamarca Villarroel, Luis Antonio; S/I; 205185
dc.information.autorucFacultad de Ciencias Biológicas; Gana Ansaldo, Juan Cristobal; 0000-0002-0400-2164; 8726
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherElsevier Editora Ltda
dc.revistaJornal de Pediatria
dc.rightsacceso restringido
dc.subjectAdolescence
dc.subjectNonalcoholic fatty pancreas disease
dc.subjectPancreatic steatosis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePrevalence of Fatty Pancreas and its relation with anthropometric values on the Growth and Obesity Cohort Study
dc.typeartículo
sipa.codpersvinculados167316
sipa.codpersvinculados1080009
sipa.codpersvinculados159736
sipa.codpersvinculados99686
sipa.codpersvinculados205185
sipa.codpersvinculados8726
sipa.trazabilidadORCID;2025-03-03
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