How the Nature of an Alpha-Nucleophile Determines a Bronsted Type-Plot and Its Reaction Pathways. An Experimental Study

Simple item page
dc.contributor.authorCampodonico, Paola R.
dc.contributor.authorTapia, Ricardo A.
dc.contributor.authorSuarez-Rozas, Cristian
dc.date.accessioned2025-01-20T21:12:40Z
dc.date.available2025-01-20T21:12:40Z
dc.date.issued2022
dc.description.abstractThe reactions between 2-chloro-5-nitro pyrimidine with a serie of alpha-nucleophile derivatives were kinetically evaluated. The kinetic study was carried out in aqueous media and the data shown an unusual split on the Bronsted type-plot, opening a controversial discussion based on reactivities and possible reaction pathways. These split Bronsted type-plots are discussed over the hypothetical transition state (TS) structures associated to concerted or stepwise mechanisms with emphasis on hydrogen bond interactions between electrophile/nucleophile pair able to determine the reactivities and the plausible reaction routes.
dc.description.funderFondecyt Grant
dc.fuente.origenWOS
dc.identifier.doi10.3389/fchem.2021.740161
dc.identifier.issn2296-2646
dc.identifier.urihttps://doi.org/10.3389/fchem.2021.740161
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93670
dc.identifier.wosidWOS:000759442200001
dc.language.isoen
dc.revistaFrontiers in chemistry
dc.rightsacceso restringido
dc.subjectSNAr reactions
dc.subjectmechanisms
dc.subjecthydrogen bond interaction
dc.subjectreactivity
dc.subjectbronsted type-plots
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHow the Nature of an Alpha-Nucleophile Determines a Bronsted Type-Plot and Its Reaction Pathways. An Experimental Study
dc.typeartículo
dc.volumen9
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas