The Value of Further Research: The Added Value of Individual-Participant Level Data

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dc.contributor.authorSaramago, Pedro
dc.contributor.authorEspinoza, Manuel A.
dc.contributor.authorSutton, Alex J.
dc.contributor.authorManca, Andrea
dc.contributor.authorClaxton, Karl
dc.date.accessioned2025-01-23T21:14:40Z
dc.date.available2025-01-23T21:14:40Z
dc.date.issued2019
dc.description.abstractJudgements based on average cost-effectiveness estimates may disguise significant heterogeneity in net health outcomes. Decisions about coverage of new interventions are often more efficient when they consider between-patient heterogeneity, which is usually operationalized as different selections for different subgroups. While most model-based cost-effectiveness studies are populated with aggregated-level sub-group estimates, individual-level data are recognized as the best source of evidence to produce unbiased and efficient estimates to explore this heterogeneity. This paper extends a previously published framework to assesses the added value of having access to individual-level data, compared to using aggregate-level data only, in the absence/presence of mutually exclusive population subgroups. Supported by a case study on the cost-effectiveness of interventions to increase uptake of smoke-alarms, the extended framework provided a quantification of the benefits foregone of not using individual-level data, pointed to the optimal number of subgroups and where further research should be undertaken. Although not indicating changes in reimbursement decisions, results showed that irrespective of using aggregate or individual-level data, no substantial additional gains are obtained if more than two subgroups are taken into account. However, depending on the evidence type used, different subgroups are revealed as warranting larger research funds. The use of individual-level data, rather than aggregate, may however influence not only the extent to which an appropriate understanding of existing heterogeneity is attained, but, more importantly, it may shape approval decisions for particular population subgroups and judgements of future research.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s40258-019-00462-x
dc.identifier.eissn1179-1896
dc.identifier.issn1175-5652
dc.identifier.urihttps://doi.org/10.1007/s40258-019-00462-x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101053
dc.identifier.wosidWOS:000469029100002
dc.issue.numero3
dc.language.isoen
dc.pagina.final284
dc.pagina.inicio273
dc.revistaApplied health economics and health policy
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Value of Further Research: The Added Value of Individual-Participant Level Data
dc.typeartículo
dc.volumen17
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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