The bone and mineral disorder of children undergoing chronic peritoneal dialysis

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dc.contributor.authorBorzych, Dagmara
dc.contributor.authorRees, Lesley
dc.contributor.authorHa, Il Soo
dc.contributor.authorChua, Annabelle
dc.contributor.authorValles, Patricia G.
dc.contributor.authorLipka, Maria
dc.contributor.authorZambrano, Pedro
dc.contributor.authorAhlenstiel, Thurid
dc.contributor.authorBakkaloglu, Sevcan A.
dc.contributor.authorSpizzirri, Ana P.
dc.contributor.authorLopez, Laura
dc.contributor.authorOzaltin, Fatih
dc.contributor.authorPrintza, Nikoleta
dc.contributor.authorHari, Pankaj
dc.contributor.authorKlaus, Guenter
dc.contributor.authorBak, Mustafa
dc.contributor.authorVogel, Andrea
dc.contributor.authorAriceta, Gema
dc.contributor.authorYap, Hui Kim
dc.contributor.authorWarady, Bradley A.
dc.contributor.authorSchaefer, Franz
dc.contributor.authorIPPN
dc.date.accessioned2024-01-10T14:21:54Z
dc.date.available2024-01-10T14:21:54Z
dc.date.issued2010
dc.description.abstractThe mineral and bone disorder of chronic kidney disease remains a challenging complication in pediatric end-stage renal disease. Here, we assessed symptoms, risk factors and management of this disorder in 890 children and adolescents from 24 countries reported to the International Pediatric Peritoneal Dialysis Network Registry. Signs of this disease were most common in North American patients. The prevalence of hyperphosphatemia increased with age from 6% in young infants to 81% in adolescents. Serum parathyroid hormone (PTH) was outside the guideline targets in the majority of patients and associated with low calcium, high phosphorus, acidosis, dialysis vintage and female gender. Serum calcium was associated with dialytic calcium exposure, serum phosphorus with low residual renal function and pubertal status. PTH levels were highest in Latin America and lowest in Europe. Vitamin D and its active analogs were most frequently administered in Europe; calcium-free phosphate binders and cinacalcet in North America. Clinical and radiological symptoms markedly increased when PTH exceeded 300 pg/ml, the risk of hypercalcemia increased with levels below 100 pg/ml, and time-averaged PTH concentrations above 500 pg/ml were associated with impaired longitudinal growth. Hence, the symptoms and management of the mineral and bone disorder of chronic kidney disease in children on peritoneal dialysis showed substantial regional variation. Our findings support a PTH target range of 100-300 pg/ml in the pediatric age group. Kidney International (2010) 78, 1295-1304; doi:10.1038/ki.2010.316; published online 1 September 2010
dc.description.funderInternational Society for Peritoneal Dialysis
dc.description.funderBaxter Health Care
dc.description.funderFresenius Medical Care
dc.description.funderIpsen
dc.description.funderPfizer
dc.description.funderIBM
dc.fechaingreso.objetodigital2024-05-02
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1038/ki.2010.316
dc.identifier.eissn1523-1755
dc.identifier.issn0085-2538
dc.identifier.pubmedidMEDLINE:20811335
dc.identifier.urihttps://doi.org/10.1038/ki.2010.316
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79813
dc.identifier.wosidWOS:000284752900014
dc.information.autorucMedicina; Vogel A;S/I;71737
dc.issue.numero12
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1304
dc.pagina.inicio1295
dc.publisherELSEVIER SCIENCE INC
dc.revistaKIDNEY INTERNATIONAL
dc.rightsacceso restringido
dc.subjectchronic dialysis
dc.subjectpediatric nephrology
dc.subjectphosphate
dc.subjectrenal
dc.subjectPARATHYROID-HORMONE LEVELS
dc.subjectHEMODIALYSIS-PATIENTS
dc.subjectRENAL OSTEODYSTROPHY
dc.subjectMETABOLIC-ACIDOSIS
dc.subjectGROWTH
dc.subjectGLANDS
dc.subjectINTERMITTENT
dc.subjectCALCITRIOL
dc.subjectPHOSPHATE
dc.subjectCALCIUM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe bone and mineral disorder of children undergoing chronic peritoneal dialysis
dc.typeartículo
dc.volumen78
sipa.codpersvinculados71737
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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