Helicobacter pylori: una causa no tradicional de deficiencia de hierro y anemia

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dc.catalogadoraba
dc.contributor.authorSerrano Honeyman, Carolina
dc.contributor.authorVillagrán T., Andrea
dc.contributor.authorHarris D., Paul R.
dc.date.accessioned2024-01-17T19:36:08Z
dc.date.available2024-01-17T19:36:08Z
dc.date.issued2012
dc.description.abstractHelicobacter Pylori (H. pylori) is the most common cause for chronic gastritis, duodenal ulcers, MALT lymphoma and gastric cancer. H. pylori has also been associated with several extra gastric diseases such as iron deficiency (ID) and iron deficiency anemia (IDA). Several mechanisms by which H. pylori might contribute to the development of ID/IDA have been proposed. Alterations in the physiology of gastric mucosa and of iron metabolism as a consequence of the infection as well as direct competition for iron by H. pylori have been proposed as possible causes for ID/IDA development. H. pylori causes alterations in gastric pH as well as in the concentration of ascorbic acid in the stomach limiting the absorption of dietary iron in the gastrointestinal tract. In addition, pro-inflammatory cytokine secretion in response to the infection, in particular IL-1β are able to modulate acid secretion and stimulate the secretion of hepcidin from the liver inhibiting liberation of iron from iron stores. These results in less iron available for eritropoyesis, thus contributing to ID/IDA development. Several studies have suggested a direct relationship between the presence of the infection and the development of ID/IDA in children, adolescents and adults. H. pylori eradication has been associated to a better response to oral iron therapy in IDA patients. However some controversy still remains regarding the role of the infection in ID/IDA and the mechanisms involved. Studies aimed to evaluate the relationship between H. pylori and acid output in gastric mucosa, as well as studies to determine iron capture in strains isolated from IDA patients are still being conducted in order the shed some definitive light in the relationship between this bacterium and ID/IDA and their contributing mechanisms.
dc.fechaingreso.objetodigital2024-01-19
dc.format.extent11 páginas
dc.fuente.origenORCID-ene24
dc.identifier.doi10.4067/S0370-41062012000100002
dc.identifier.eissn0717-6228
dc.identifier.issn0370-4106
dc.identifier.scopusidSCOPUS_ID:84860897106
dc.identifier.urihttps://doi.org/10.4067/S0370-41062012000100002
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80586
dc.information.autorucEscuela de Medicina; Serrano Honeyman, Carolina; 0000-0001-5523-0637; 15296
dc.information.autorucEscuela de Medicina; Harris D., Paul R.; 0000-0001-6226-0957; 80706
dc.issue.numero1
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final23
dc.pagina.inicio13
dc.revistaRevista Chilena de Pediatría
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 DEEDAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHelicobacter pylori
dc.subjectIron deficiency
dc.subjectIron uptake
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleHelicobacter pylori: una causa no tradicional de deficiencia de hierro y anemia
dc.title.alternativeHelicobacter pylori: A non traditional cause of iron deficiency and anemia
dc.typeartículo
dc.volumen83
sipa.codpersvinculados15296
sipa.codpersvinculados80706
sipa.indexWoS
sipa.indexPubmed
sipa.indexSCOPUS
sipa.indexScielo
sipa.indexmedẽs
sipa.indexLatindex
sipa.trazabilidadORCID;2024-01-08
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