RENIN-SECRETING TUMOR - CASE-REPORT
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Date
1980
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Abstract
Renin-secreting tumor, though rare, should be considered in assessing severe hyperreninemic, hypertensive patients. An 18-yr-old girl with hypokalemic hyperreninemic hyperaldosteronism was studied. No angiographic lesion was detected. The plasma renin activity (PRA) of the right/left renal vein was 7.3. With a presumptive diagnosis of renin-secreting tumor (RST), the patient was operated on, and a cortical nodule was found on the right lower pole. Partial nephrectomy was followed by a rapid fall in PRA (half-life, 33-44 min) and normalization of blood pressure (BP). At 3 1/2 mo. postoperatively, the patient showed normotension, normopokalemia, normal aldosterone and slightly elevated PRA unresponsive to postural changes and furosemide treatment. Tumoral PRA secretion responded to postural stimulus, spironolactone use and nitroprusside-induced hypotension. Neither the high aldosterone excretion nor hyperreninemia decreased after 3 days of DOCA [deoxycorticosterone acetate]; this agrees with a previously reported case, suggesting the usefulness of this test in the diagnosis of RST.