Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression

Simple item page
dc.catalogadoryvc
dc.contributor.authorSatija, Saurabh
dc.contributor.authorKaur, Harpreet
dc.contributor.authorTambuwala, Murtaza M.
dc.contributor.authorSharma, Prabal
dc.contributor.authorVyas, Manish
dc.contributor.authorKhurana, Navneet
dc.contributor.authorSharma, Neha
dc.contributor.authorBakshi, Hamid A.
dc.contributor.authorCharbe, Nitin B.
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorAljabali, Alaa A.
dc.contributor.authorNammi, Srinivas
dc.contributor.authorDureja, Harish
dc.contributor.authorSingh, Thakur G.
dc.contributor.authorGupta, Gaurav
dc.contributor.authorDhanjal, Daljeet S.
dc.contributor.authorDua, Kamal
dc.contributor.authorChellappan, Dinesh K.
dc.contributor.authorMehta, Meenu
dc.date.accessioned2023-08-24T22:15:46Z
dc.date.available2023-08-24T22:15:46Z
dc.date.issued2021
dc.description.abstractHypoxia is an integral part of the tumor microenvironment, caused primarily due to rapidly multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic pathways, HIF-1 transcription factor activation is one of the widely investigated pathways in the hypoxic tumor microenvironment (TME). HIF-1 is known to activate several adaptive reactions in response to oxygen deficiency in tumor cells. HIF-1 has two subunits, HIF-1 beta (constitutive) and HIF-1 alpha (inducible). The HIF-1 alpha expression is largely regulated via various cytokines (through PI3K-ACT-mTOR signals), which involves the cascading of several growth factors and oncogenic cascades. These events lead to the loss of cellular tumor suppressant activity through changes in the level of oxygen via oxygen-dependent and oxygen-independent pathways. The significant and crucial role of HIF in cancer progression and its underlying mechanisms have gained much attention lately among the translational researchers in the fields of cancer and biological sciences, which have enabled them to correlate these mechanisms with various other disease modalities. In the present review, we have summarized the key findings related to the role of HIF in the progression of tumors.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2023-08-24
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.2174/1874467214666210120154929
dc.identifier.eissn1874-4702
dc.identifier.issn1874-4672
dc.identifier.pubmedidMEDLINE_ID:33494692
dc.identifier.urihttps://doi.org/10.2174/1874467214666210120154929
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74494
dc.identifier.wosidWOS:000674682600006
dc.information.autorucEscuela de Química ; Zacconi, Flavia C. M. ; 0000-0002-3676-0453 ; 1011127
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final332
dc.pagina.inicio321
dc.publisherBentham Science Publ. LTD
dc.revistaCurrent Molecular Pharmacologyes_ES
dc.rightsacceso restringido
dc.subjectHypoxia
dc.subjectnormoxia
dc.subjectmicroenvironment
dc.subjecttumor
dc.subjectHIF
dc.subjecthydroxylation
dc.subjectcancer progression
dc.subjectARYL-HYDROCARBON RECEPTOR
dc.subjectVHL TUMOR-SUPPRESSOR
dc.subjectPAS DOMAIN PROTEIN-1
dc.subjectFACTOR 1-ALPHA
dc.subjectFACTOR-I
dc.subjectTRANSCRIPTION FACTOR
dc.subjectGENE-EXPRESSION
dc.subjectSIGNAL-TRANSDUCTION
dc.subjectDNA-BINDING
dc.subjectMAP KINASE
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHypoxia-Inducible Factor (HIF): Fuel for Cancer Progression
dc.typeartículo de revisión
dc.volumen14
sipa.indexWoS
sipa.trazabilidadWOS;18-03-2022
sipa.trazabilidadORCID;2023-08-20
sipa.trazabilidadHistorial Académico;21-09-2021
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
RESUMEN_Hypoxia-Inducible Factor (HIF) Fuel for Cancer.pdf
Size:
106.56 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas