Associations of the CTLA-4 polymorphism with type 1 diabetes in Chilean population: case-parent design

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dc.catalogadorjlo
dc.contributor.authorAngel, Bárbara
dc.contributor.authorBalic, Iván
dc.contributor.authorSantos Martín, José Luis
dc.contributor.authorCodner, Ethel
dc.contributor.authorCarrasco, Elena
dc.contributor.authorPérez-Bravo, Francisco
dc.date.accessioned2024-01-22T14:56:15Z
dc.date.available2024-01-22T14:56:15Z
dc.date.issued2009
dc.description.abstractCTLA-4 plays a key role in T cells regulation. We analysed the CTLA-4 +49A/G and -318C/T polymorphisms in 178 cases of type 1 diabetes and their parents (534 individuals) from Santiago, Chile. A significant overall association with T1D (p = 0.028) was observed, possibly due to an overtransmission of the G-T haplotype. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
dc.description.funderFONDECYT
dc.fuente.origenSIPA
dc.identifier.doi10.1016/j.diabres.2009.05.019
dc.identifier.issn0168-8227
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0168822709002459 (
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80873
dc.identifier.wosidWOS:000208997400003
dc.information.autorucEscuela de Medicina; Santos Martín, José Luis; 0000-0003-2895-0369; 1005923
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.finale36
dc.pagina.inicioe34
dc.revistaDiabetes Research and Clinical Practice
dc.rightsacceso restringido
dc.subjectCTLA-4
dc.subjectPolymorphism
dc.subjectTDT analysis
dc.subjectType 1 diabetes
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociations of the CTLA-4 polymorphism with type 1 diabetes in Chilean population: case-parent design
dc.typeartículo
dc.volumen85
sipa.codpersvinculados1005923
sipa.trazabilidadHistorial Académico;09-07-2021
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