Fast and reliable calibration of solid substrate fermentation kinetic models using advanced non-linear programming techniques

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dc.contributor.authorMacarena Araya, M.
dc.contributor.authorArrieta, Juan J.
dc.contributor.authorRicardo Perez Correa, J.
dc.contributor.authorBiegler, Lorenz T.
dc.contributor.authorJorquera, Hector
dc.date.accessioned2024-01-10T12:05:28Z
dc.date.available2024-01-10T12:05:28Z
dc.date.issued2007
dc.description.abstractCalibration of mechanistic kinetic models describing microorganism growth and secondary metabolite production on solid substrates is difficult due to model complexity given the sheer number of parameters needing to be estimated and violation of standard conditions of numerical regularity. We show how advanced non-linear programming techniques can be applied to achieve fast and reliable calibration of a complex kinetic model describing growth of Gibberella fujikuroi and production of gibberellic acid on an inert solid support in glass columns. Experimental culture data was obtained under different temperature and water activity conditions. Model differential equations were discretized using orthogonal collocations on finite elements while model calibration was formulated as a simultaneous solution/optimization problem. A special purpose optimization code (IPOPT) was used to solve the resulting large-scale non-linear program. Convergence proved much faster and a better fitting model was achieved in comparison with the standard sequential solution/optimization approach. Furthermore, statistical analysis showed that most parameter estimates were reliable and accurate.
dc.fechaingreso.objetodigital2024-05-17
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.2225/vol10-issue1-fulltext-8
dc.identifier.issn0717-3458
dc.identifier.urihttps://doi.org/10.2225/vol10-issue1-fulltext-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76013
dc.identifier.wosidWOS:000248639200005
dc.information.autorucIngeniería;Jorquera H;S/I;100302
dc.information.autorucIngeniería;Pérez-Correa J;S/I;100130
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final60
dc.pagina.inicio48
dc.publisherUNIV CATOLICA DE VALPARAISO
dc.revistaELECTRONIC JOURNAL OF BIOTECHNOLOGY
dc.rightsacceso abierto
dc.subjectdynamic models
dc.subjectGibberella fujikuroi
dc.subjectGibberellic acid
dc.subjectnonlinear models
dc.subjectparameter estimation
dc.subjectsecondary metabolites
dc.subjectsolid substrate cultivation
dc.subjectGIBBERELLA-FUJIKUROI GROWTH
dc.subjectSTATE FERMENTATION
dc.subjectACID PRODUCTION
dc.subject.ods12 Responsible Consumption and Production
dc.subject.ods07 Affordable and Clean Energy
dc.subject.odspa12 Producción y consumo responsable
dc.subject.odspa07 Energía asequible y no contaminante
dc.titleFast and reliable calibration of solid substrate fermentation kinetic models using advanced non-linear programming techniques
dc.typeartículo
dc.volumen10
sipa.codpersvinculados100302
sipa.codpersvinculados100130
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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