Nephrotic Syndrome and Acute Tubular Necrosis Due to Meloxicam Use

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dc.contributor.authorVega, Jorge
dc.contributor.authorGoecke, Helmuth
dc.contributor.authorMendez, Gonzalo P.
dc.contributor.authorGuarda, Francisco J.
dc.date.accessioned2024-01-10T13:15:26Z
dc.date.available2024-01-10T13:15:26Z
dc.date.issued2012
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) are widely used by patients all over the world. Five to eighteen percent of the patients who receive NSAIDs can suffer from kidney-related side effects. Among them, the most relevant are sodium and water retention, hyponatremia, worsening of hypertension or preexisting cardiac failure, hyperkalemia, acute kidney injury, chronic kidney disease, papillary necrosis, nephrotic syndrome (NS), and acute interstitial nephritis. We report the case of a 65-year-old woman who developed acute tubular necrosis and NS a few days after receiving 15 mg of meloxicam (MLX) for 3 days for tendinitis. Steroid therapy was begun with normalization of kidney function after 7 weeks of treatment. NS (minimal change disease) was characterized by frequent remissions and relapses as prednisone was lowered under 30 mg/day. Azathioprine (100 mg/day) was added on the fifth month of diagnosis and a complete remission was finally obtained 4 years after hospital admittance. In her last medical checkup, 8 years after her debut and receiving azathioprine (50 mg) and prednisone (5 mg/day), renal function was normal (creatinine 1.0 mg/dL and creatinine clearance 80 mL/min/1.73 m(2)), proteinuria was 150 mg/day and there was no hematuria or hypertension.
dc.description.abstractThe aim of communicating this case is to raise a warning about these renal side effects of MLX. After thorough review of literature, only one other report with the same findings was found.
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3109/0886022X.2012.718953
dc.identifier.eissn1525-6049
dc.identifier.issn0886-022X
dc.identifier.pubmedidMEDLINE:22963504
dc.identifier.urihttps://doi.org/10.3109/0886022X.2012.718953
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78501
dc.identifier.wosidWOS:000310016300026
dc.information.autorucMedicina;Guarda F;S/I;149942
dc.information.autorucMedicina;Mendez G;S/I;123121
dc.issue.numero10
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1347
dc.pagina.inicio1344
dc.publisherTAYLOR & FRANCIS LTD
dc.revistaRENAL FAILURE
dc.rightsacceso restringido
dc.subjectacute tubular necrosis
dc.subjectacute kidney injury
dc.subjectnephrotic syndrome
dc.subjectminimal change disease
dc.subjectmeloxicam
dc.subjectnon-steroidal anti-inflammatory drugs
dc.subjectNONSTEROIDAL ANTIINFLAMMATORY DRUGS
dc.subjectACUTE INTERSTITIAL NEPHRITIS
dc.subjectMINIMAL-CHANGE GLOMERULOPATHY
dc.subjectRENAL-FAILURE
dc.subjectNEPHROPATHY
dc.subjectCELECOXIB
dc.subjectPATIENT
dc.subjectDISEASE
dc.subjectDICLOFENAC
dc.subjectSECONDARY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNephrotic Syndrome and Acute Tubular Necrosis Due to Meloxicam Use
dc.typeartículo
dc.volumen34
sipa.codpersvinculados149942
sipa.codpersvinculados123121
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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