Understanding Risk Factors for Alzheimer's Disease: Interplay of Neuroinflammation, Connexin-based Communication and Oxidative Stress

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dc.catalogadorpva
dc.contributor.authorQuintanilla, Rodrigo A.
dc.contributor.authorOrellana Roca, Juan Andrés
dc.contributor.authorBernhardi Montgomery, Rommy von
dc.date.accessioned2024-10-16T17:08:02Z
dc.date.available2024-10-16T17:08:02Z
dc.date.issued2012
dc.description.abstractAlzheimer's disease (AD) is an age-related neurodegenerative disease characterized by dementia and the presence of amyloid plaques and anomalous tau aggregates. Although pathophysiological mechanisms are still unclear, neuroinflammation and glial cell dysfunction have been identified as conspicuous components of AD. Glial cell dysfunction is associated with dysregulated production of inflammation mediators and generation of both reactive oxygen species (ROS) and reactive nitrogen species (RNS), which affect synapses and induce neuronal damage. Importantly, both increased neuroinflammation and ROS/RNS production by glia dysregulate communication mediated by connexin-based channels in brain cells, which could further affect oxidative balance and neuronal viability. Recent evidence suggests that connexin-based channels could be involved in AD pathogenesis. Here we discuss how aging affects neuroinflammation, oxidative stress, and connexin-based channels and the potential relevance of these changes for AD. Understanding how they cooperate as pathogenic mechanisms of AD is promising for the discovery of new therapeutic strategies against neurodegenerative disorders.
dc.fuente.origenConveris
dc.identifier.doi10.1016/j.arcmed.2012.10.016
dc.identifier.eissn1873-5487
dc.identifier.issn0188-4409
dc.identifier.pubmedidPMID: 23142264
dc.identifier.urihttps://doi.org/10.1016/j.arcmed.2012.10.016
dc.identifier.urihttps://publons.com/wos-op/publon/8438807/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88270
dc.identifier.wosidWOS:000314378000007
dc.information.autorucEscuela de Medicina; Quintanilla, Rodrigo A.; S/I; 1010409
dc.information.autorucFacultad de Ciencias Biológicas; Orellana Roca, Juan Andrés; 0000-0003-4076-207X; 126007
dc.information.autorucEscuela de Medicina; Bernhardi Montgomery, Rommy von; S/I; 62523
dc.issue.numero8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final644
dc.pagina.inicio632
dc.publisherElsevier Inc.
dc.revistaArchives of Medical Research
dc.rightsacceso restringido
dc.subjectGap junctions
dc.subjectHemichannels
dc.subjectGlia
dc.subjectInflammation
dc.subjectNeurodegeneration
dc.subjectOxidative stress
dc.subjectAb
dc.subjectAlzheimer’s disease
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleUnderstanding Risk Factors for Alzheimer's Disease: Interplay of Neuroinflammation, Connexin-based Communication and Oxidative Stress
dc.typeartículo de revisión
dc.volumen43
sipa.codpersvinculados1010409
sipa.codpersvinculados126007
sipa.codpersvinculados62523
sipa.trazabilidadConveris;20-07-2021
sipa.trazabilidadORCID;2024-10-14
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