Effects of an antioxidants cocktail on glucose metabolism at rest, during exercise, and during a glucose load in healthy young subjects

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dc.catalogadordfo
dc.contributor.authorRodríguez, Iván
dc.contributor.authorPaez Espinosa, Enma Verónica
dc.contributor.authorZbinden-Foncea, Hermann
dc.contributor.authorEcheverrÍa González, Francisca Cecilia
dc.contributor.authorCastro-Sepúlveda, Mauricio
dc.date.accessioned2024-10-09T15:28:16Z
dc.date.available2024-10-09T15:28:16Z
dc.date.issued2023
dc.description.abstractBackground: Reactive oxygen species (ROS) regulate glucose metabolism (GM) in skeletal muscle by improving the translocation of GLUT4. Antioxidant supplementation could block this physiological effect, altering glucose signaling during exercise. However, there is limited evidence in humans on whether antioxidant intake affects GM. Therefore, we aimed to determine the effect of an antioxidant cocktail (AOC) on GM at rest and during metabolic challenges. Methods: Ten healthy male subjects received AOC supplementation (1000 mg of Vitamin C, 600 IU of Vitamin E, and 600 mg of α-lipoic acid) or placebo (2.000 mg of talc) before two trials conducted 7 days apart. Trial 1: AOC 120 and 90 minutes before an endurance exercise (EEX) bout at 60 % of maximal oxygen uptake (VO2max ); Trial 2: AOC 120 and 90 minutes before an oral glucose tolerance test (OGTT; 75 g glucose). Measurements of gas exchange and capillary blood samples were collected every 15 minutes during both trials. Results: AOC supplementation increased resting glucose levels (p<0.05). During Trial 1 (EEX), the AOC increased carbohydrate oxidation (CHOox) (p= 0.03), without effect in glucose blood levels. During Trial 2 (OGTT), the AOC supplementation had no significant effect on GM parameters. Conclusion: Acute supplementation with AOC increased resting glucose levels and CHOox during EEX in healthy subjects, with no effect on GM during the OGTT. Keywords: α-lipoic acid; Glucose metabolism; Substrate oxidation; Vitamin C, Vitamin E.
dc.fuente.origenORCID
dc.identifier.doi10.4067/s0717-75182023000600593
dc.identifier.urihttp://dx.doi.org/10.4067/s0717-75182023000600593
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88136
dc.information.autorucDepartamento de Ciencias de la Salud; Echeverria Gonzalez Francisca Cecilia; S/I; 1232657
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final601
dc.pagina.inicio593
dc.revistaRevista chilena de nutrición
dc.rightsacceso abierto
dc.rights.licenseAtribución/Reconocimiento-NoComercial 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/deed.es
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffects of an antioxidants cocktail on glucose metabolism at rest, during exercise, and during a glucose load in healthy young subjects
dc.title.alternativeEfecto de un cóctel de antioxidantes sobre el metabolismo de la glucosa en reposo, durante el ejercicio y durante una carga de glucosa en sujetos jóvenes sanos
dc.typeartículo
dc.volumen50
sipa.codpersvinculados1232657
sipa.trazabilidadORCID;2024-03-11
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