A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia

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dc.contributor.authorJimenez Fonseca, Paula
dc.contributor.authorCarmona-Bayonas, Alberto
dc.contributor.authorMatos Garcia, Ignacio
dc.contributor.authorMarcos, Rosana
dc.contributor.authorCastanon, Eduardo
dc.contributor.authorAntonio, Maite
dc.contributor.authorFont, Carme
dc.contributor.authorBiosca, Merce
dc.contributor.authorBlasco, Ana
dc.contributor.authorLozano, Rebeca
dc.contributor.authorRamchandani, Avinash
dc.contributor.authorBeato, Carmen
dc.contributor.authorMartinez de Castro, Eva
dc.contributor.authorEspinosa, Javier
dc.contributor.authorMartinez-Garcia, Jeronimo
dc.contributor.authorGhanem, Ismael
dc.contributor.authorHernando Cubero, Jorge
dc.contributor.authorAragon Manrique, Isabel
dc.contributor.authorGarcia Navalon, Francisco
dc.contributor.authorSevillano, Elena
dc.contributor.authorManzano, Aranzazu
dc.contributor.authorVirizuela, Juan
dc.contributor.authorGarrido, Marcelo
dc.contributor.authorMondejar, Rebeca
dc.contributor.authorAngeles Arcusa, Maria
dc.contributor.authorBonilla, Yaiza
dc.contributor.authorPerez, Quionia
dc.contributor.authorGallardo, Elena
dc.contributor.authordel Carmen Soriano, Maria
dc.contributor.authorCardona, Merce
dc.contributor.authorSanchez Lasheras, Fernando
dc.contributor.authorJesus Cruz, Juan
dc.contributor.authorAyala, Francisco
dc.date.accessioned2025-01-23T21:30:50Z
dc.date.available2025-01-23T21:30:50Z
dc.date.issued2016
dc.description.abstractBackground: We sought to develop and externally validate a nomogram and web-based calculator to individually predict the development of serious complications in seemingly stable adult patients with solid tumours and episodes of febrile neutropenia (FN).
dc.description.abstractPatients and methods: The data from the FINITE study (n = 1133) and University of Salamanca Hospital (USH) FN registry (n = 296) were used to develop and validate this tool. The main eligibility criterion was the presence of apparent clinical stability, defined as events without acute organ dysfunction, abnormal vital signs, or major infections. Discriminatory ability was measured as the concordance index and stratification into risk groups.
dc.description.abstractResults: The rate of infection-related complications in the FINITE and USH series was 13.4% and 18.6%, respectively. The nomogram used the following covariates: Eastern Cooperative Group (ECOG) Performance Status >= 2, chronic obstructive pulmonary disease, chronic cardiovascular disease, mucositis of grade >= 2 (National Cancer Institute Common Toxicity Criteria), monocytes <200/mm(3), and stress-induced hyperglycaemia. The nomogram predictions appeared to be well calibrated in both data sets (Hosmer-Lemeshow test, P>0.1). The concordance index was 0.855 and 0.831 in each series. Risk group stratification revealed a significant distinction in the proportion of complications. With a >= 116-point cutoff, the nomogram yielded the following prognostic indices in the USH registry validation series: 66% sensitivity, 83% specificity, 3.88 positive likelihood ratio, 48% positive predictive value, and 91% negative predictive value.
dc.description.abstractConclusions: We have developed and externally validated a nomogram and web calculator to predict serious complications that can potentially impact decision-making in patients with seemingly stable FN.
dc.fuente.origenWOS
dc.identifier.doi10.1038/bjc.2016.118
dc.identifier.eissn1532-1827
dc.identifier.issn0007-0920
dc.identifier.urihttps://doi.org/10.1038/bjc.2016.118
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101461
dc.identifier.wosidWOS:000376431200009
dc.issue.numero11
dc.language.isoen
dc.pagina.final1198
dc.pagina.inicio1191
dc.revistaBritish journal of cancer
dc.rightsacceso restringido
dc.subjectClinical Index of Stable Febrile Neutropenia
dc.subjectCISNE
dc.subjectnomogram
dc.subjectseemingly stable patients
dc.subjectrisk prediction
dc.subjectcomplications
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia
dc.typeartículo
dc.volumen114
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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